组学技术在中耳炎领域的应用  

Application of Omics Technology in Management of Otitis Media

作　　者：张凯[1] 吴远程 唐丽欢 胡娟[2] 都梦贤 李博[1] ZHANG Kai;WU Yuancheng;TANG Lihuan;HU Juan;DU Mengxian;LI Bo(Hearing and Speech Rehabilitation Institute,School of Special Education and Rehabilitation,Binzhou Medical University,Yantai,Shandong 264003,China;不详)

机构地区：[1]滨州医学院特殊教育与康复学院听觉言语康复科学研究院,烟台264003 [2]西安交通大学第二附属医院耳鼻咽喉头颈外科

出　　处：《中华耳科学杂志》2025年第2期305-309,共5页Chinese Journal of Otology

基　　金：国家自然科学基金(82371137;82171143;81530030);山东省自然科学基金(ZR2024MH263);山东省优质专业学位教学案例库项目(SDYAL2022186;SDYKC2023184);滨州医学院教学改革与研究项目(JYKTMP2021013)。

摘　　要：中耳炎是指由细菌或病毒引起中耳结构的炎性病变,为临床耳鼻喉科中的常见疾病,好发于儿童,以耳痛、听力减退和耳内流脓为常见的症状。目前,临床上常使用抗菌药物与手术等手段对中耳炎进行治疗,但存在用药后不良反应和并发症等问题。因此,迫切需要对中耳炎的病理生理机制进行研究,以探寻更好的治疗方法。高通量技术的迅速发展使组学技术能够同时全面分析大量相似生物分子或单一分子。利用组学技术发现的新生物标志物使研究者加深对疾病病理生理机制的理解,为疾病诊断、治疗和预防提供新的思路。我们将从基因组学、蛋白质组学、代谢组学、转录组学和微生物组学5个方面综述组学技术应用于中耳炎领域的最新进展。Otitis media(OM)refers to an inflammatory lesion in the middle ear caused by bacterial or viral infections,which is a common disease in clinical otolaryngology,usually involving children with common symptoms including ear pain,hearing loss and ear discharge.At present,antibiotics and surgery are often used to treat OM in the clinic,but there are adverse reactions and complications after medication.Therefore,it is urgent to study the pathophysiological mechanism of OM in order to improve treatment methods.The rapid development of highthroughput technology enables omics techniques to comprehensively analyze a large number of similar biomolecules or single molecules simultaneously.Discovery of new biomarkers using omics technology deepens researchers'understanding of the pathological and physiological mechanisms of OM,providing new ideas for diagnosis,treatment and prevention.We will review the latest developments in the application of omics technologies in the management of OM from five aspects:genomics,proteomics,metabolomics,transcriptomics and microbiomics.

关 键 词：中耳炎 基因组学 蛋白质组学 代谢组学 转录组学 微生物组学 

分 类 号：R76[医药卫生—耳鼻咽喉科]