海南省海口市2016-2023年家蝇抗药性发展动态  

Insecticide resistance tendency of Musca domestica in Haikou,Hainan Province,China,2016-2023

作　　者：杨新艳[1] 李慧慧 林怡[1] 钟汶兵 蔡芳[1] 林春燕[1] YANG Xin-yan;LI Hui-hui;LIN Yi;ZHONG Wen-bing;CAI Fang;LIN Chun-yan(Vector Control Department of Haikou Center for Disease Control and Prevention,Haikou,Hainan 570203,China)

机构地区：[1]海口市疾病预防控制中心病媒生物防制科,海南海口570203

出　　处：《中国媒介生物学及控制杂志》2025年第1期34-38,共5页Chinese Journal of Vector Biology and Control

摘　　要：目的掌握海口市家蝇对几种常见卫生杀虫剂的抗药性发展动态,为卫生杀虫剂的科学使用和规范指导提供依据。方法在海口市农贸市场、餐饮外环境、公园绿化带、城市居民区4种生境采集家蝇,采用点滴法对菊酯类、有机磷类和氨基甲酸酯类中5种常见卫生杀虫剂进行抗药性生物测定,采用SPSS 26.0软件进行Probit回归分析,计算半数致死剂量(LD_(50))、回归方程及95%置信区间和抗性倍数。结果2017、2019和2023年家蝇野外种群对马拉硫磷的LD_(50)值分别为0.0642、0.0774和0.1590μg/只,抗性倍数分别为12.84、15.48和31.80,抗性水平呈现逐年增长趋势;对残杀威LD_(50)值分别为0.3860、0.3891和0.4548μg/只,抗性倍数分别为1.30、1.31和1.53,抗性水平持续保持敏感;2016、2017、2019和2023年家蝇对高效氯氰菊酯LD_(50)值分别为0.0037、0.0377、0.0429和0.0546μg/只,抗性倍数分别为1.00、10.21、11.62和14.79;对氯菊酯LD_(50)值分别为0.0200、0.1046、0.1297和0.1470μg/只,抗性倍数分别为2.80、14.63、18.13和20.55,高效氯氰菊酯和氯菊酯抗性水平均呈现逐年不断增长趋势;溴氰菊酯LD_(50)值分别为0.0041、0.0217、0.0213和0.0115μg/只,抗性倍数分别为1.79、9.70、9.53和5.14,呈现先升高后逐年降低的趋势。结论2016-2023年,除对残杀威抗性水平持续保持敏感外,海口市家蝇对马拉硫磷、高效氯氰菊酯、氯菊酯和溴氰菊酯等4种卫生杀虫剂产生了不同抗性发展趋势。在防制过程中,应根据家蝇的抗药性情况选择合适的卫生杀虫剂。Objectives To investigate the resistance tendency of Musca domestica to several commonly used hygienic insecticides in Haikou,Hainan Province,China,so as to provide a basis for the scientific use and standardized guidance of hygienic insecticides use.Methods M.domestica were collected in four habitats of farmers'market,external environment of restaurants,park and public green belt,and urban residential area in Haikou.The topical application method was used to determine the resistance levels of M.domestica to five commonly used hygienic insecticides in pyrethroids,organophosphates,and carbamates.A Probit regresion analysis was performed using SPSS 26.0 software to calculate the median lethal dose(LD_(50)),regression equation,95%confidence interval,and resistance ratio.Results In 2017,2019,and 2023,the LD_(50)values of malathion for field M.domestica populations were 0.0642,0.0774,and 0.1590μg/inds,and the resistance ratios were 12.84,15.48,and 31.80,respectively,showing an increasing trend in the resistance level year by year;the LD_(50)values of propoxur were 0.3860,0.3891,and 0.4548μg/inds,and the resistance ratios were 1.30,1.31,and 1.53,respectively,showing that the resistance level continued to remain sensitive.In 2016,2017,2019,and 2023,the LD_(50)values of beta-cypermethrin for M.domestica were 0.0037,0.0377,0.0429,and 0.0546μg/inds,and the resistance ratios were 1.00,10.21,11.62,and 14.79,respectively;the LD_(50)values of permethrin were 0.0200,0.1046,0.1297,and 0.1470μg/inds,and the resistance ratios were 2.80,14.63,18.13,and 20.55,respectively.The resistance levels to beta-cypermethrin and permethrin showed an increasing trend year by year;the LD_(50)values of deltamethrin were 0.0041,0.0217,0.0213,and 0.0115μg/inds,and the resistance ratios were 1.79,9.70,9.53,and 5.14,respectively,showing a trend of first rising and then falling.Conclusions From 2016 to 2023,M.domestica in Haikou developed different resistance tendency to four hygienic insecticides including malathion,beta-cypermethrim,permethrin

关 键 词：家蝇 卫生杀虫剂 抗药性 海口市 

分 类 号：R384.2[医药卫生—医学寄生虫学] S481.4[医药卫生—基础医学]