中药抗肿瘤活性成分调控自噬性细胞死亡的研究进展  

Progress in the regulation of autophagic cell death by anti-tumor active ingredients of traditional Chinese medicine

作　　者：刘媛 杨齐林 韩波[2] 符雷蕾 LIU Yuan;YANG Qi-lin;HAN Bo;FU Lei-lei(School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China;StateKey Laboratory of Southwestern Chinese Medicine Resources,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]西南交通大学生命科学与工程学院,四川成都610031 [2]西南特色中药资源国家重点实验室,成都中医药大学药学院,四川成都611137

出　　处：《药学学报》2025年第3期533-549,共17页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(82073998,82374020);四川省自然科学基金面上项目(2024NSFSC0632)。

摘　　要：细胞自噬(autophagy)是一种可以降解细胞自身成分、维持细胞稳态的重要生理过程。在癌症发生发展过程中,自噬因其具有双重作用而起到促进或是抑制的作用,靶向自噬被认为是治疗癌症的重要手段。中医理论认为自噬在机体内具有调节“阴阳平衡、正邪平衡”的作用,基于“扶正祛邪”的理论使用中药活性成分靶向自噬来治疗癌症已被证明有效。此外,自噬细胞死亡作为II型程序性细胞死亡方式,肿瘤细胞发生自噬性死亡往往伴随着自噬特征,调控自噬性细胞死亡是自噬发挥抗肿瘤作用的关键途径。近年来,越来越多的研究发现中药活性成分在癌症治疗中具有良好效果。其中,调控自噬性细胞死亡是中药活性成分实现其抗肿瘤药效的重要途径,如姜黄素、槲皮素等通过此途径发挥抗肿瘤作用。本文概述了中医理论对癌症和自噬的认识,并基于化合物的结构分类系统性总结了靶向自噬性细胞死亡的中药小分子化合物及其作用机制。最后,对开发中药来源化合物靶向自噬细胞死亡治疗肿瘤进行了总结和展望,希望可以为后续抗肿瘤中药小分子药物的全新发现提供线索。Autophagy is an important physiological process that can degrade cellular components and maintain cellular homeostasis.In the process of cancer development,autophagy plays a dual role in promoting or inhibiting autophagy,and targeting autophagy is considered to be an important means of cancer treatment.According to Chinese medicine theory,autophagy has the function of regulating the balance of Yin and Yang,and the balance of good and evil in the organism,and based on the theory of"supporting the positive and dispelling the evil",the use of active ingredients of traditional Chinese medicine(TCM)to target autophagy has been proven to be effective in the treatment of cancer.In addition,autophagic cell death,as a type II programmed cell death,is often accompanied by autophagic features,and the regulation of autophagic cell death is an important way for autophagy to achieve anti-tumor effects.In recent years,more and more studies have found that the active ingredients of TCM have good effects in cancer treatment,among which,targeting autophagic cell death is an important way for TCM active ingredients to achieve anti-tumor effects.This paper outlines the understanding of cancer and autophagy in Chinese medicine theory,and summarizes the current Chinese medicine small molecule compounds targeting autophagic cell death and their mechanisms of action based on the classification of natural medicines.Finally,the development of Chinese medicine-derived compounds targeting autophagic cell death for the treatment of diseases is summarized and prospected,which hopefully can provide clues for subsequent exploration and research.

关 键 词：细胞自噬 自噬性细胞死亡 中医理论 中药活性成分 扶正祛邪 抗肿瘤活性成分 

分 类 号：R966[医药卫生—药理学]