基于TRPV通道的辛味中药药理作用研究进展  

Research progress in the pharmacological effects of pungent Chinese medicine based on TRPV channels

作　　者：王佳佳 杨志军[1,2,3] 杨秀娟 牛鹏贤[1] 李硕 段国建 田一虹[1] 吉庆云 WANG Jia-jia;YANG Zhi-jun;YANG Xiu-juan;NIU Peng-xian;LI Shuo;DUAN Guo-jian;TIAN Yi-hong;JI Qing-yun(l.Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Northwest China-Tibetan Medicine Co-construction and Collaborative Innovation Center,Lanzhou 730000,China;Gansu Pharmaceutical Industry Innovation Research Institute,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]西北中藏药省部共建协同创新中心,甘肃兰州730000 [3]陇药产业创新研究院,甘肃兰州730000

出　　处：《药学学报》2025年第3期679-692,共14页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(82160755);甘肃省教育厅创新基金(2024A-094);甘肃省青年博士支持项目(2025QB-066);甘肃省中药质量与标准研究重点实验室开放基金项目(ZYZL2024-01);西北中藏药协同创新中心开放基金(Xbzzy-2022-08)。

摘　　要：瞬时受体电位香草酸(TRPV)作为一类重要的非选择性阳离子通道,与多种生理和病理过程密切相关。辛味是中药五味学说中的重要性味之一,具有解表、行气、活血等作用,主治病证多样。现代研究表明,众多辛味中药中的活性成分具有调节TRPV离子通道的功能。本文旨在从TRPV通道的生物学特性,辛味中药现代研究进程及其在炎症、疼痛等病理过程中的作用机制来探讨基于TRPV通道的辛味中药药理作用研究进展,以期揭示辛味中药的科学内涵,亦为中药药性的现代研究提供新的研究思路和模式。Transient receptor potential vanilloid(TRPV),an important class of non-selective cation channels,is closely associated with a variety of physiological and pathological processes.Pungent flavour is one of the important flavours in the doctrine of five flavours in traditional Chinese medicine,which has the functions of relieving the epidermis,moving the Qi,activating the blood and so on,which has a variety of main treatments.Modern research has shown that the active ingredients in numerous pungent Chinese medicine have the ability to modulate TRPV channels.The purpose of paper is to explore the biological characteristics of TRPV channels,the modern research process of pungent Chinese medicine and its mechanism in inflammation,pain and other pathological processes.This paper discusses the research progress of the pharmacological action of pungent Chinese medicine based on TRPV channel,in order to reveal the scientific connotation of spicy traditional Chinese medicine,and also provide new research ideas and models for the modern research of Chinese medicine.

关 键 词：辛味中药 瞬时受体电位香草酸通道 药理作用 临床应用 物质基础 

分 类 号：R966[医药卫生—药理学]