中医药防治结直肠癌复发转移的研究进展  

Research progress on the prevention and treatment of colorectal cancer recurrence and metastasis by traditional Chinese medicine

作　　者：王华苗 张春泽[2,3] WANG Hua-miao;ZHANG Chun-ze(Tianjin University of Traditional Chinese Medicine,Tianjin 301600,China;Department of Colorectal Surgery,Tianjin Union Medical Center,Tianjin 300121,China;Tianjin Institute of Coloproctology,Tianjin 300121,China)

机构地区：[1]天津中医药大学,天津301600 [2]天津市人民医院结直肠外科,天津300121 [3]天津市结直肠病研究所,天津300121

出　　处：《药学学报》2025年第3期693-699,共7页Acta Pharmaceutica Sinica

基　　金：天津市科技计划项目(23JCZXJC00390);京津冀基础研究合作专项。

摘　　要：结直肠癌(colorectal cancer,CRC)是消化系统常见的恶性肿瘤之一,具有较高的发病率和病死率。复发转移是结直肠癌患者死亡的最根本原因。目前,结直肠癌主要采取手术治疗、术后放化疗及免疫治疗等方式。然而,这些治疗方式所伴随的不良反应以及较高的复发转移率,给患者造成了沉重的身心负担,严重影响了患者的生活质量。大量的临床与实验研究表明,中药能缓解结直肠癌患者临床症状、缓解患者的痛苦、减轻放化疗所带来的不良反应、提高其生活质量、预防结直肠癌根治术后的复发和转移、延长患者生存期、提高患者生存率等。本文将从中医药防治结直肠癌的中医理论、中医药防治结直肠癌复发转移的优势以及中医药可通过调节肠道菌群防治结直肠癌3个方面进行如下综述。Colorectal cancer(CRC),a prevalent and deadly digestive malignancy,primarily causes death through recurrence and metastasis.Current treatments include surgery,radiotherapy,chemotherapy,and immunotherapy,but they have significant side effects and high recurrence rates.Research shows traditional Chinese medicine(TCM)can alleviate symptoms,reduce adverse reactions,enhance quality of life,prevent recurrence and metastasis post-surgery,and improve survival rates.This review explores TCM's theoretical framework,advantages in CRC management,and potential in modulating intestinal flora for CRC prevention and treatment.

关 键 词：结直肠癌 复发转移 中医药 减毒增效 肠道菌群 

分 类 号：R966[医药卫生—药理学]