微针给药系统在感染性伤口的应用研究进展  

Research progress in the application of microneedles drug delivery system in infectious wounds

作　　者：武超雄 于庆雨 黄晨露 张琳华[1] 朱敦皖[1] WU Chao-xiong;YU Qing-yu;HUANG Chen-lu;ZHANG Lin-hua;ZHU Dun-wan(Institute of Biomedical Engineering,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin Key Laboratory of Biomedical Materials,Tianjin 300192,China)

机构地区：[1]中国医学科学院,北京协和医学院生物医学工程研究所,天津市生物医学材料重点实验室,天津300192

出　　处：《药学学报》2025年第3期711-720,共10页Acta Pharmaceutica Sinica

摘　　要：皮肤创伤和慢性疾病引起的伤口,往往因感染而使得愈合过程变得复杂和困难。在此种情况下,伤口的愈合不仅是一个漫长持续的过程,而且易产生疤痕性修复。常规的敷料及抗生素治疗存在药物递送效率低下及药物系统毒性的问题。近年来,微针技术在减轻感染和促进伤口愈合方面得到了广泛的应用。微针不仅可以穿破皮肤角质层及生物被膜增强药物给药效率、减轻药物不良反应,而且可以与多种材料结合实现对伤口的多重治疗及监测。本文将讨论感染伤口愈合机制、微针的分类以及它们在感染性伤口治疗中的应用。Wound healing caused by skin trauma and chronic diseases is often complicated and difficult due to infection.In such cases,the wound healing process is not only a long and continuous one,but also prone to scar repair.Conventional dressings and antibiotic treatments suffer from issues such as low drug delivery efficiency and systemic toxicity.In recent years,microneedle technology has been widely used to reduce infection and promote wound healing.Microneedles can not only penetrate the skin stratum corneum and biofilm to enhance drug delivery efficiency and reduce drug side effects,but also can be combined with a variety of materials to achieve multiple treatments and monitoring of wounds.This article will discuss the healing mechanism of infected wounds,the classification of microneedles,and their applications in the treatment of infected wounds.

关 键 词：微针 伤口 抗菌 抗炎 感染 

分 类 号：R944[医药卫生—药剂学]