健脾扶正汤加减对晚期肝癌患者癌因性疲乏的影响及机制研究  

The influence and mechanism of Modified Spleen-strengthening Decoction soup on cancer fatigue in patients with advanced liver cancer

作　　者：杨涛 赵庆华 武步涛 YANG Tao;ZHAO Qinghua;WU Butao(Department of Gastroenterology,Kaifeng Second Traditional Chinese Medicine Hospital,Kaifeng,Henan,475000,China;Kaifeng Traditional Chinese Medicine Hospital)

机构地区：[1]开封市第二中医院消化科,河南开封475000 [2]开封市中医院

出　　处：《中国中西医结合消化杂志》2025年第2期145-148,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：目的:探讨健脾扶正汤加减对晚期肝癌患者癌因性疲乏的影响及机制。方法:选取2022年6月—2024年6月收治的原发性晚期肝癌患者86例,按照随机数字表法分为治疗组和研究组,每组43例。治疗组予以放化疗治疗,研究组在此基础上予以健脾扶正汤加减治疗。比较2组治疗前后癌因性疲乏量表评分、卡氏性能状态评分量表评分及氧化应激反应指标的差异,比较2组治疗后生活质量评分。结果:研究组病灶控制率为88.37%,治疗组为69.77%,研究组的病灶控制率显著高于治疗组(P<0.05)。治疗后2组癌因性疲乏量表评分均显著低于治疗前,研究组更低(P<0.05);治疗后2组卡氏性能状态评分量表评分均显著升高,研究组更高(P<0.05)。治疗前2组中性粒细胞弹性蛋白酶、可溶性血管细胞黏附分子1比较差异无统计学意义(P>0.05);治疗后2组中性粒细胞弹性蛋白酶明显增加,研究组更高,2组可溶性血管细胞黏附分子1明显降低,研究组更低,差异均有统计学意义(P<0.05)。治疗后研究组生活质量评分明显高于治疗组(P<0.05)。结论:健脾扶正汤因其抑制氧化应激指标的特性,可消除原发性晚期肝癌患者的癌因性疲乏。Objective To explore the effect and mechanism of modified spleen-strengthening decoction on cancer fatigue in patients with advanced liver cancer.Methods A cohort of 86 patients diagnosed with advanced primary liver cancer and admitted from June 2022 to June 2024 were enrolled.Patients were randomly divided into a treatment group and a study group using a random number table method,with 43 patients in each group.The treatment group underwent radiotherapy and chemotherapy,while the study group received spleen-strengthening decoction intervention on this basis.The differences in cancer fatigue scale scores,the Karnofsky Performance Status Scale scores,and oxidative stress response indicators between two groups before and after the intervention were compared.The quality of life scores between the two groups after intervention were compared.Results The lesion control rate of the study group was 88.37%,while that of the treatment group was 69.77%.The lesion control rate of the study group was significantly higher than that of the treatment group(P<0.05).After treatment,the cancer fatigue scale scores in both groups were significantly lower than before intervention,and the study group had even lower scores(P<0.05).After treatment,both groups showed a significant improvement in the Karnofsky Performance Status Scale scores,with the study group achieving higher scores(P<0.05).There was no significant difference in neutrophil elastase and soluble vascular cell adhesion molecule-1 between the two groups before the intervention(P>0.05).After treatment,the neutrophil elastase increased significantly in both groups,and the study group had higher levels;The soluble vascular cell adhesion molecule-1 decreased significantly in both groups,and the study group had lower levels.The differences were statistically significant(P<0.05).After treatment,the quality of life score in the study group was significantly higher than that in the treatment group(P<0.05).Conclusion The spleen-strengthening decoction can eliminate cancer-induced f

关 键 词：健脾扶正汤加减 晚期肝癌 癌因性疲乏 病灶控制率 

分 类 号：R273[医药卫生—中西医结合]