超声瞬时弹性技术诊断慢性乙型肝炎患者肝纤维化的效能分析  

Analysis of the Efficacy of Ultrasound Instantaneous Elasticity Technology in Diagnosing Liver Fibrosis in Patients with Chronic Hepatitis B

作　　者：刘静媛 LIU Jing-yuan(Ultrasound Diagnosis Department of the 907th Hospital of the Joint Logistic Support Force,Fujian Nanping 353000)

机构地区：[1]联勤保障部队第907医院超声诊断科,福建南平353000

出　　处：《中国医疗器械信息》2025年第5期104-106,共3页China Medical Device Information

基　　金：第九〇七医院院管课题项目(项目名称:多模态便携式超声评估军事训练伤的应用价值研究,项目编号:907kt202202)。

摘　　要：目的:探讨超声瞬时弹性技术诊断慢性乙型肝炎患者肝纤维化的效能分析。方法:选择2023年9月~2024年9月在联勤保障部队第907医院诊治的慢性乙型肝炎患者150例为观察对象,所有患者都给予超声瞬时弹性技术检查,记录肝脏硬度值。同时所有患者都给予血清肝纤维化指标检测、病理检查,判定诊断的效能。结果:在150例患者中,病理诊断为肝纤维化60例,占比40.00%(肝纤维化组),其中轻度42例,中度10例,重度8例。肝纤维化组的超声瞬时弹性肝脏硬度值与非肝纤维化组对比增高(P<0.05)。肝纤维化组的血清透明质酸、层粘连蛋白、Ⅲ型前胶原肽和Ⅳ型胶原含量与非肝纤维化组对比增加(P<0.05)。在150例患者中,Spearman相关分析显示肝纤维化与血清透明质酸、层粘连蛋白、Ⅲ型前胶原肽和Ⅳ型胶原含量等存在正相关性(P<0.05)。超声瞬时弹性技术判断为肝纤维化62例,超声瞬时弹性技术诊断慢性乙型肝炎患者肝纤维化的灵敏度与特异性为98.33%、96.67%。受试者操作特征曲线显示超声瞬时弹性技术诊断慢性乙型肝炎患者肝纤维化的曲线下面积为0.877。结论:慢性乙型肝炎患者肝纤维化的发生率比较高,伴随有超声瞬时弹性肝脏硬度增加,肝纤维化水平与患者的血清纤维化指标存在相关性。Objective:To explore the efficacy of ultrasound instantaneous elasticity technology in diagnosing liver fibrosis in patients with chronic hepatitis B.Methods:From September 2023 to September 2024,150 cases of patients with chronic hepatitis B who were diagnosed and treated in the 907th Hospital of the Joint Logistic Support Force were selected.All patients were underwent ultrasound instantaneous elasticity technology examination and recorded liver hardness stiffness values.At the same time,all patients were given serum liver fibrosis index testing and pathological examination to determine the diagnostic efficacy.Results:There were 60 cases of were diagnosed with liver fibrosis by pathology,accounting for 40.00%(liver fibrosis group)in the 150 cases which 42 cases were mild,10 cases were moderate,and 8 cases were severe.The ultrasound instantaneous elastic liver stiffness value in the liver fibrosis group were significantly higher than that in the non liver fibrosis group(P<0.05).The levels of serum hyaluronic acid,laminin,type Ⅲ procollagen peptide,and type Ⅳ collagen in the liver fibrosis group were significantly increased compared to the non liver fibrosis group(P<0.05).In the 150 patients,Spearman correlation analysis showed a positive correlation between liver fibrosis and serum levels of hyaluronic acid,laminin,type Ⅲ procollagen peptide,and type Ⅳ collagen(P<0.05).Ultrasound instantaneous elasticity technique were used to diagnose 62 cases of liver fibrosis.The sensitivity and specificity of ultrasound instantaneous elasticity technique in diagnosing liver fibrosis in patients with chronic hepatitis B were 98.33% and 96.67%,respectively.Conclusion:The incidence of liver fibrosis in patients with chronic hepatitis B is relatively high,accompanied by an increase in ultrasound instantaneous elasticity of the liver hardness.There are correlation between the level of liver fibrosis and the patient’s serum fibrosis indicators.

关 键 词：超声瞬时弹性技术 慢性乙型肝炎 肝纤维化 肝脏硬度 

分 类 号：R445.1[医药卫生—影像医学与核医学]