颞浅动脉-大脑中动脉搭桥术治疗烟雾病的临床疗效及对脑血流量的影响  

Clinical efficacy of superficial temporal artery-middle cerebral artery bypass in the treatment of moyamoya disease and its effect on cerebral blood flow

作　　者：李军鹏 杨恒阳 Li Junpeng;Yang Hengyang(Xuchang Beihai Hospital,Xuchang 461111,Henan;Xinye County People's Hospital,Nanyang,HenanProvince 473500)

机构地区：[1]许昌北海医院,河南许昌461111 [2]新野县人民医院,河南南阳473500

出　　处：《辽宁医学杂志》2025年第1期46-49,共4页Medical Journal of Liaoning

摘　　要：目的探讨颞浅动脉-大脑中动脉搭桥术治疗烟雾病的临床疗效及对脑血流量的影响。方法以我院2018年1月—2021年2月收治的62例烟雾病患者为研究对象进行回顾性分析,所有患者均行颞浅动脉-大脑中动脉搭桥术治疗。对比治疗前后14天所有患者的治疗效果、神经功能、免疫功能以及脑血流动力学指标。结果治疗后所有患者Rankin修订量表评分(mRS)、神经功能缺损评分(NIHSS)评分低于治疗前,KPS评分高于治疗前(P<0.05);治疗后所有患者CD4+、CD3+、CD4+/CD8+相关免疫功能指标明显低于治疗前(P<0.05);治疗后所有患者相对脑血容量(rCBV)、相对脑血流量(rCBF)相关脑血流动力学指标明显高于治疗前(P<0.05)。结论对烟雾病患者应用颞浅动脉-大脑中动脉搭桥术能够明显减轻患者症状严重程度,提升神经功能与免疫功能,恢复患者脑血流动力学,提升患者生存质量,治疗效果显著。Objective Investigation of the clinical efficacy of superficial bypass surgery of the central cerebral artery temporal artery in the treatment of Moyamoya disease and its effects on cerebral blood flow.Methods A retrospective analysis was performed on 62-patients with Moyamoya disease who were admitted to our hospital from January 2018 to February 2021.All patients underwent superficial middle cerebral artery bypass surgery.Compare treatment efficacy,neurological function,immune function and cerebral hemodynamic indicators of all patients before and after 14-day treatment.Results After treatment,the Rankin revised scale score(mRS)and neurological deficit score(NIHSS)scores of all patients were lower than those before treatment,and the KPS scores were higher than those before treatment(P<0.05).After treatment,all patients had CD4+,CD3+,CD4+/The CD8+-related immune function indexes were significantly lower than those before treatment(P<0.05);the relative cerebral blood volume(rCBV)and relative cerebral blood flow(rCBF)-related cerebral hemodynamic indexes of all patients after treatment were significantly higher than those before treatment(P<0.05).Conclusion Superficial temporal artery-middle cerebral artery bypass grafting in patients with moyamoya disease can significantly reduce the severity of symptoms,improve neurological and immune functions,restore cerebral hemodynamics,and improve the quality of life of patients.The treatment effect is remarkable.

关 键 词：颞浅动脉-大脑中动脉搭桥术 烟雾病 脑血流量 神经功能 

分 类 号：R74[医药卫生—神经病学与精神病学]