基于PI3K/Akt信号通路探讨中药促进缺血性脑卒中后血管新生的作用机制研究进展  

Mechanism of Chinese Medicine in Promoting Angiogenesis After Ischemic Stroke Based on PI3K/Akt Signaling Pathway:A Review

作　　者：王晓娅 刘昊飞[1] 刘向哲[1] WANG Xiaoya;LIU Haofei;LIU Xiangzhe(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;The First Clinical School of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院,郑州450000 [2]河南中医药大学第一临床医学院,郑州450000

出　　处：《中国实验方剂学杂志》2025年第7期265-274,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点研发计划项目(2022YFC3501103);河南省科技攻关计划项目(242102311277);河南省中医药学科领军人才项目(豫卫中医函[2021]8号);河南省“双一流”创建中医学科研专项(HSRP-DFCTCM-2023-2-18)。

摘　　要：缺血性脑卒中是一种常见的脑血管疾病,其主要病理特征是由于局部脑组织因血液供应不足而导致的缺氧和营养缺乏。血管新生,即在已有血管基础上形成新的血管网络,对于增加脑组织缺血区域的血流量、恢复血供和氧供、改善疾病预后具有重要意义。这一复杂过程受到多种因素的调控,包括细胞因子、生长因子及信号通路等,其中,磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)信号通路被认为是一个关键的调节通路,不仅在抗细胞凋亡和促细胞存活中发挥重要作用,调控着细胞生长、分化、迁移和存活等过程,还深度参与调控血管新生的过程。中药对治疗脑卒中具有多成分、多靶点、多通路的独特优势,在治疗缺血性脑卒中方面展现出显著潜力,近年来研究发现中药可以通过PI3K/Akt信号通路促进缺血性脑卒中后的血管新生,该文以PI3K/Akt信号通路为研究切入点,从调控微小RNA(miRNA)、内皮祖细胞(EPCs)、细胞凋亡、通路上游促血管生成因子及下游靶分子方面深入探讨了中药单体活性成分、提取物、衍生物、药对和中药复方在缺血性脑卒中后促进血管新生的机制,并详细阐述了相关研究进展,旨在揭示中药如何通过这一关键信号通路,发挥其在缺血性脑卒中治疗中的潜在效用,为临床治疗提供理论依据。Ischemic stroke is a common cerebrovascular disease,characterized by hypoxia and nutritional deficiency in local brain tissue due to insufficient blood supply.Angiogenesis,the formation of new vascular networks on the basis of existing blood vessels,is of great significance for increasing blood flow in the ischemic area of brain tissue,restoring blood and oxygen supply,and improving disease prognosis.This complex process is regulated by various factors,including cytokines,growth factors,and signaling pathways.Among these,the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)signaling pathway is considered a key regulatory pathway.It not only plays an important role in anti-apoptosis and promoting cell survival,but also regulates cell growth,differentiation,migration,and survival,while deeply participating in the regulation of angiogenesis.Chinese medicine offers unique advantages with its multi-component,multi-target,and multi-pathway approach in the treatment of stroke,showing significant potential in treating ischemic stroke.In recent years,it has been found that Chinese medicine can promote angiogenesis after ischemic stroke through the PI3K/Akt signaling pathway.This paper focuses on the PI3K/Akt signaling pathway as the research entry point,and explores in-depth the mechanisms by which Chinese medicine monomers,active components,extracts,derivatives,drug pairs,and Chinese medicine compounds promote angiogenesis after ischemic stroke.The research discusses the regulation of microRNAs(miRNA),endothelial progenitor cells(EPCs),apoptosis,upstream proangiogenic factors,and downstream target molecules.The paper also elaborates on related research progress,aiming to reveal how Chinese medicine can exert its potential utility in ischemic stroke treatment through this key signaling pathway,providing a theoretical basis for clinical treatment.

关 键 词：磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)信号通路 缺血性脑卒中 中药 血管新生 作用机制 研究进展 

分 类 号：R2-031[医药卫生—中西医结合] R287[医药卫生—中医学] R285.5