黄连解毒汤的药理机制研究进展  

Pharmacological Mechanism of Huanglian Jiedutang:A Review

作　　者：李多静 邢永发 王保和[3] LI Duojing;XING Yongfa;WANG Baohe(School of Graduate Studies,Tianjin University of Traditional Chinese Medicine(TCM),Tianjin 301617,China;The Second Affiliated Hospital of Tianjin University of TCM,Tianjin 300250,China;First Teaching Hospital of Tianjin University of TCM,Tianjin 300193,China)

机构地区：[1]天津中医药大学研究生院,天津301617 [2]天津中医药大学第二附属医院,天津300250 [3]天津中医药大学第一附属医院,天津300193

出　　处：《中国实验方剂学杂志》2025年第7期275-283,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：科技部国家科技重大专项(2018ZX09734-002);天津市教委科研计划项目(2021KJ167)。

摘　　要：黄连解毒汤作为一种传统中药方剂,具有清热解毒的功效。该文对该方剂的药效物质基础、药理作用机制及研究进行了综述。现代研究显示,黄连解毒汤富含生物碱类、黄酮类、苷类等多种活性成分。药理作用机制方面,黄连解毒汤具有减轻炎症反应、抗菌、调节肠道菌群、调节细胞紊乱、改善铁代谢紊乱、调节糖脂代谢、调节血管内皮功能、抗肿瘤、改善脑缺血、减轻肝损伤的作用,具有多层次、多角度、多靶点的治疗特点,在治疗多种疾病中具有显著疗效。通过多学科交叉研究,如网络药理学与分子对接技术的应用,代谢组学与蛋白质组学研究等,揭示了黄连解毒汤在多种疾病治疗中的潜在作用机制。然而,黄连解毒汤的研究仍面临一些挑战和问题,包括深入探究其复杂药理作用机制、评估不同疾病和人群中的应用效果与安全性,以及中药质量控制等。未来应加强整合运用现代科技手段,结合中医药理论,深入研究其复杂药理作用机制,以期为黄连解毒汤的临床应用提供更坚实的理论基础和实践指导。Huanglian Jiedutang(HLJDT),a traditional Chinese herbal formula,is known for its heat-clearing and detoxifying effects.This article reviewed the material basis,pharmacological mechanism of action,and research on HLJDT.Modern research has shown that HLJDT is rich in alkaloids,flavonoids,glycosides,and other active ingredients.In terms of pharmacological mechanisms of action,HLJDT has anti-inflammatory and antibacterial effects,and it can regulate intestinal flora and cell disorder,improve iron metabolism disorder,control glucose and lipid metabolism,and exert vascular endothelial functions,with anti-tumor effects,thus improving cerebral ischemia and reducing liver damage.Its therapeutic actions are multilayered,multi-faceted,and multi-targeted,showing significant efficacy in treating various diseases.Interdisciplinary research,such as the combined application of network pharmacology with molecular docking technology,as well as metabolomics with proteomics,has revealed the potential mechanism of HLJDT in treating various diseases.However,the research on HLJDT still faces some challenges,including the need for an in-depth exploration of its complex pharmacological mechanism of action,evaluation of its efficacy and safety across different diseases and populations,and quality control of traditional Chinese medicine.Future research should integrate modern scientific and technological approaches with traditional Chinese medicine principles to further investigate HLJDT's complex pharmacological mechanism of action,providing theoretical and practical support for its clinical use.

关 键 词：黄连解毒汤 物质基础 药代动力学 药理作用机制 综述 

分 类 号：R289[医药卫生—方剂学] R285[医药卫生—中药学] R259[医药卫生—中医学]