自噬在心血管疾病中的作用及中医药治疗进展  

Role of Autophagy in Cardiovascular Diseases and Traditional Chinese Medicine Treatment:A Review

作　　者：赵依婷 秦合伟 魏霞 ZHAO Yiting;QIN Hewei;WEI Xia(Rehabilitation Medicine College,Henan University of Chinese Medicine,Zhengzhou 450046,China;Zhumadian Hospital of Traditional Chinese Medicine,Zhumadian 463000,China)

机构地区：[1]河南中医药大学康复医学院,郑州450046 [2]驻马店市中医院,河南驻马店463000

出　　处：《中国实验方剂学杂志》2025年第7期284-292,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金面上项目(82374551);河南省高等学校重点科研项目(24B360003);河南中医药大学2023年度研究生科研创新能力提升计划项目(2023KYCX080,2023KYCX079)。

摘　　要：心血管疾病是主要的非感染类疾病之一,具有高发病率和死率的特点,严重影响患者生存质量,因此迫切需要寻找一种安全有效的治疗方法。自噬作为细胞的一种程序性死亡方式,已被证明与高血压病、糖尿病心肌病、心肌缺血再灌注损伤、心力衰竭、动脉粥样硬化等多种心血管疾病发病机制有关,是中医药临床干预治疗心血管疾病的潜在靶点之一。自噬对心血管疾病的发生发展具有双向调控作用,其具体作用主要取决于自噬程度和疾病病理发展阶段。近年来的研究已经证实,中药可以通过直接调控自噬或在自噬的调控下与氧化应激、炎症、凋亡相互影响防治心血管疾病,具有多靶点、多组分且不良反应少的独特优势。该文通过对近年来自噬在常见的心血管疾病(糖尿病心肌病、心肌缺血再灌注损伤、心力衰竭、动脉粥样硬化)中的作用及中药有效成分、中成药和中药复方干预自噬治疗心血管疾病的实验研究进行综述,并对研究不足之处进行总结,以期为心血管疾病的临床治疗提供科学的理论依据和治疗策略。Cardiovascular diseases,a group of major non-infectious diseases,are characterized by high morbidity and mortality,significantly influencing patients'quality of life.Hence,it is imperative to discover a secure and efficacious treatment approach.As a form of programmed cell death,autophagy has been demonstrated to be associated with the pathogeneses of hypertension,diabetic cardiomyopathy,myocardial ischemia-reperfusion injury,heart failure,atherosclerosis,and other cardiovascular disorders.It serves as one of the potential targets for the clinical intervention in cardiovascular diseases by traditional Chinese medicine(TCM).Autophagy exerts dual regulatory effects on the occurrence and development of cardiovascular diseases,and its specific effect predominantly depends on the extent of autophagy and the pathological stage of diseases.Recent studies have confirmed that TCM can prevent and treat cardiovascular diseases by directly regulating autophagy or interacting with oxidative stress,inflammation,and apoptosis under the regulation of autophagy,exhibiting the unique advantages of multiple targets,multiple components,and mild adverse reactions.This article reviews the experimental research progress in the role of autophagy and the intervention by active components and compound prescriptions of TCM and Chinese patent medicines in common cardiovascular diseases(such as diabetic cardiomyopathy,myocardial ischemia-reperfusion injury,heart failure,and atherosclerosis)in recent years and summarizes the research shortcomings,providing a theoretical basis and strategies for the clinical treatment of cardiovascular diseases.

关 键 词：自噬 心血管疾病 中医药治疗 作用机制 综述 

分 类 号：R242[医药卫生—中医临床基础] R259[医药卫生—中医学] R277