药食同源保肝中药的抗炎抗氧化作用  

Research Advances on Anti-inflammatory and Anti-oxidation Effect of Medicinal and Edible Herbs Liver-protecting Chinese Medicine

作　　者：赵静涵 朱正望 王琳琳 朱平生 苗明三[2,3] ZHAO Jinghan;ZHU Zhengwang;WANG Linlin;ZHU Pingsheng;MIAO Mingsan(The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450000,China;School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学第一临床医学院,郑州450000 [2]河南中医药大学药学院,郑州450046 [3]豫药全产业链研发河南省协同创新中心,郑州450046

出　　处：《中国实验方剂学杂志》2025年第7期293-301,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82074340);河南省“双一流”创建学科中医学科学研究专项(HSRP-DFCTCM-2023-1-19,HSRPDFCTCM-2023-8-31,HSRP-DFCTCM-2023-8-32)。

摘　　要：肝脏与炎症和氧化还原反应密切相关,炎症是身体的先天防御系统,用于清除有害刺激并参与肝脏伤口愈合反应。氧化应激与炎症途径的激活有关,持续的炎症和相应的再生伤口愈合反应可诱导纤维化、肝硬化,发展至终末期肝病或肝细胞癌,最终导致死亡。部分“药食同源”中药已有效应用于临床,显示出保护肝脏的能力。该文综述了肝脏与氧化应激反应与炎症反应的关系,并以2020年版《中华人民共和国药典》与新世纪第五版《中药学》为依据对110味“药食同源”中药进行整理,结果发现木瓜、甘草、决明子、余甘子、沙棘、枣、金银花、生姜、栀子、桔梗、荷叶、蒲公英、芦根、蜂蜜、山银花、黄芪、灵芝、天麻、杜仲叶19味中药被明确记载具有保肝作用。保肝机制以抗炎、抗氧化、抑制脂质过氧化为主,部分中药还可通过抑制肝炎病毒、肝癌细胞生长,调节胆汁酸代谢发挥肝保护作用。此外重点分析其通过抗氧化、抗炎作用实现保肝作用的动物实验生物学机制,发现其通过多通路、多靶点发挥作用,为“药食同源”中药在肝脏疾病治疗策略中的作用提供新的思路。The liver is closely associated with inflammation and the redox response,and inflammation is the body's innate defense system for clearing away harmful stimuli and participating in the liver's wound-healing response.Oxidative stress is associated with the activation of inflammatory pathways,and sustained inflammation and the corresponding regenerative wound healing response can induce fibrosis,cirrhosis,progression to end-stage liver disease or hepatocellular carcinoma,and ultimately death.Some"medicine and food homology"traditional Chinese medicine has been used in clinical effect,showing the ability to protect the liver.This paper reviewed the relationship between liver and oxidative stress response and inflammation response,and sorted out 110"medicine and food same origin"traditional Chinese medicines based on the Chinese Pharmacopoeia(2020 edition)and the Chinese materia medica.The results showed that common floweringqince fruit,licorice root,cassia seed,emblic,seabuckthorn fruit,Chinese date,honeysuckle,ginger,cape jasmine fruit,platycodon root,lotus leaf,dandelion,reed root,honey,mountain honeysuckle,milkvetch root,glossy ganoderma,Gastrodia gastrodia and eucommia leaf were recorded to have liver protection effects.The liver protection mechanism is mainly anti-inflammatory,antioxidant and lipid peroxidation inhibition.Some Chinese herbs can also play a liver protection role by inhibiting the growth of hepatitis virus and liver cancer cells and regulating bile acid metabolism.In addition,the biological mechanism of its liver protection effect through antioxidant and antiinflammatory effects in animal experiments was analyzed,and it was found that it plays a role through multiple pathways and multiple targets,providing new ideas for the role of"medicine and food homology"traditional Chinese medicine in the treatment strategy of liver diseases.

关 键 词：药食同源 肝损伤 炎症反应 氧化应激 研究进展 

分 类 号：R285[医药卫生—中药学] R289[医药卫生—中医学] R287