基于PINK1/Parkin信号通路介导的线粒体自噬探讨中西医防治糖尿病肾病的研究进展  

Exploration of Traditional Chinese and Western Medicine in Prevention and Treatment of DKD Based on Mitochondrial Autophagy Mediated by PINK1/Parkin Signaling Pathway:A Review

作　　者：刘润生 张晓东[2] 李昭晴 王静[1] 张婧璐 金丽霞[2] LIU Runsheng;ZHANG Xiaodong;LI Zhaoqing;WANG Jing;ZHANG Jinglu;JIN Lixia(Heilongjiang University of Chinese Medicine,Harbin 150006,China;The Fourth Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150070,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150006 [2]黑龙江中医药大学附属第四医院,哈尔滨150070

出　　处：《中国实验方剂学杂志》2025年第7期302-313,共12页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：黑龙江省自然科学基金面上项目(H2016066);国家中医药考试科研课题(TC2023007);黑龙江省中医药科研课题项目(ZHY2024-024);黑龙江省卫生健康委科研课题(20222121020963);黑龙江中医药大学附属第四医院人才专项基金支持项目(FSRC2024ZD02)。

摘　　要：糖尿病肾病是较为常见的慢性肾脏病之一,其成因多复杂,极易进展至终末期肾病,目前治疗效果仍有待提高。肾脏作为人体重要的排泄器官,具有排出代谢废物、调节体液平衡、维持机体内环境稳定等生理功能,这些高度复杂的生物化学过程均依赖于线粒体所提供的能量支持,线粒体功能异常是造成肾脏损伤的关键因素,而线粒体稳态失衡是导致线粒体功能异常的重要环节,糖尿病肾病的发生与发展往往伴随着肾脏细胞中线粒体稳态的失衡,线粒体自噬作为调控线粒体稳态的手段,对糖尿病肾病的防治至关重要。而PTEN诱导假定激酶1(PINK1)/帕金蛋白(Parkin)通路是调控线粒体自噬最为经典的途径之一,目前研究发现有些药物能通过调控PINK1/Parkin信号通路,靶向调节肾脏细胞线粒体稳态以发挥肾保护作用。特别是中医药调控PINK1/Parkin通路介导的线粒体自噬机制对于早期及中期的糖尿病肾病影响显著。该文从PINK1/Parkin通路出发探讨PINK1/Parkin通路在线粒体自噬及糖尿病肾病中的作用机制,并对PINK1/Parkin通路介导的线粒体自噬对糖尿病肾病的影响进行综述,同时探究中西医调控PINK1/Parkin介导线粒体自噬对糖尿病肾病的治疗作用,旨在从PINK1/Parkin调控线粒体自噬角度为中西医防治糖尿病肾病拓宽思路。Diabetic kidney disease(DKD)is one of the more common chronic kidney diseases,and its causes are complex.DKD is very easy to progress to end-stage renal disease,and the current therapeutic effect still needs to be improved.As an important excretive organ of the human body,the kidney has physiological functions such as discharging metabolic waste,regulating fluid balance,and maintaining the stability of the body's internal environment.These highly complex biochemical processes all depend on the energy support provided by mitochondria.Mitochondrial dysfunction is a key factor causing kidney injury,and the imbalance of mitochondrial homeostasis is an important link leading to mitochondrial dysfunction.The occurrence and development of DKD are often accompanied by the imbalance of mitochondrial homeostasis in renal cells.Mitochondrial autophagy,as a means of regulating mitochondrial homeostasis,is very important for the prevention and treatment of DKD.The PTEN-induced putative kinase 1(PINK1)/Parkin pathway is one of the most classical pathways to regulate mitochondrial autophagy.Recent studies have found that some drugs can regulate the PINK1/Parkin signaling pathway to target mitochondrial homeostasis and exert renoprotective effects.In particular,traditional Chinese medicine has a significant effect on early and middle stage DKD by regulating PINK1/Parkin pathway-mediated mitochondrial autophagy.This article discussed the mechanism of PINK1/Parkin pathway in mitochondrial autophagy and DKD and reviewed the effect of PINK1/Parkin pathway-mediated mitochondrial autophagy on DKD.At the same time,it explored the therapeutic effect of traditional Chinese and western medicine on DKD mediated by PINK1/Parkin-mediated mitochondrial autophagy,aiming to broaden the ideas of traditional Chinese and western medicine for the prevention and treatment of DKD from the perspective of PINK1/Parkin regulating mitochondrial autophagy.

关 键 词：中西医 糖尿病肾病(DKD) PTEN诱导假定激酶1(PINK1)/帕金蛋白(Parkin)信号通路 作用机制 研究进展 

分 类 号：R259[医药卫生—中西医结合] R587.2[医药卫生—中医内科学] R256.5[医药卫生—中医学]