黄芩有效成分治疗骨质疏松症相关信号通路的研究进展  

Pathways Related to Osteoporosis Treatment with Active Ingredients of Scutellaria Baicalensis:A Review

作　　者：杜健强 秦文秀 殷雪松 赵丹 潘志铖 张起[4] 古恩鹏 DU Jianqiang;QIN Wenxiu;YIN Xuesong;ZHAO Dan;PAN Zhicheng;ZHANG Qi;GU Enpeng(Tianjin University of Traditional Chinese Medicine(TCM),Tianjin 301617,China;The Second Affiliated Hospital of Tianjin University of TCM,Tianjin 300250,China;Gansu University of Chinese Medicine,Lanzhou 730000,China;Binhai New Area Hospital of TCM(Fourth Teaching Hospital of Tianjin University of TCM),Tianjin 300450,China)

机构地区：[1]天津中医药大学,天津301617 [2]天津中医药大学第二附属医院,天津300250 [3]甘肃中医药大学,兰州730000 [4]天津市滨海新区中医医院暨天津中医药大学第四附属医院,天津300450

出　　处：《中国实验方剂学杂志》2025年第7期325-330,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：古恩鹏天津市名中医传承工作室建设项目;天津市卫生健康委员会中医、中西医结合科研课题(2023192);天津市卫生健康科技项目(TJWJ2022QN107)。

摘　　要：随着全球人口老龄化,骨质疏松症(OP)正在成为世界范围内主要的公共卫生问题。现阶段临床上常用的抗骨质疏松药物因诸多不良反应导致应用受限。因此,探索并制定更加有效、安全的策略来预防和治疗OP成为当前该领域的研究重点。近年来,中医药治疗OP的临床疗效及优势逐渐被大众认可。随着OP防治的中药药理学研究不断深入,相关研究发现,中药黄芩的有效成分可通过调控Wnt/β-连环蛋白(β-catenin)、骨保护素/核转录因子-κB受体活化因子配体/核转录因子-κB受体活化因子(OPG/RANKL/RANK)、骨形态发生蛋白-2(BMP-2)/Smad、丝裂原活化蛋白激酶(MAPK)及哺乳动物雷帕霉素靶蛋白(mTOR)等相关信号通路促进骨形成或抑制骨吸收,从而治疗OP。但是目前黄芩有效成分治疗OP的相关研究比较零散,导致学者无法对其研究及应用现状进行系统认识。因此,笔者通过对国内外相关文献进行梳理,明晰黄芩有效成分治疗OP的现存机制,并探讨其中的一些问题,为中医药防治OP提供参考和思路。With the aging of the global population,osteoporosis(OP)is becoming a major public health concern worldwide.Currently,the commonly used anti-osteoporosis drugs in clinical practice have limited application due to many side effects.Therefore,developing more effective and safer strategies for the prevention and treatment of OP has become a research focus in this field.In recent years,the clinical efficacy and advantages of traditional Chinese medicine(TCM)in treating OP have been gradually recognized.With the deepening pharmacological research on TCM for OP prevention and treatment,it is found that the active ingredients of Scutellaria baicalensis can promote bone formation or inhibit bone resorption by regulating signaling pathways,including Wnt/β-catenin,osteoprotegerin(OB)/receptor activator of nuclear factor-κB ligand(RANKL)/RANK(OPG/RANKL/RANK),and bone morphogenetic protein 2(BMP-2)/Smad,mitogen-activated protein kinase(MAPK),and mammalian target of rapamycin(mTOR).However,existing research on active ingredients of S.baicalensis for OP treatment is scattered,making it difficult for scholars to gain a systematic understanding of its research and application.This review summarized the literature on the active ingredients of S.baicalensis in OP treatment worldwide,clarified their mechanisms of action,and explored some issues,providing references for the integration of TCM in OP prevention and treatment.

关 键 词：骨质疏松症 黄芩 有效成分 骨代谢 信号通路 

分 类 号：R336[医药卫生—人体生理学] R259[医药卫生—基础医学] R282