瓜薤香丹方联合比索洛尔对稳定型心绞痛患者心肌缺血总负荷及血清抵抗素水平的影响  

Effects of Guaxie Xiangdan recipe combined with bisoprolol on total ischemic burden and serum resistin level in patients with stable angina pectoris

作　　者：张梅芳[1] 李晓丽 薛刚 吕军 ZHANG Meifang;LI Xiaoli;XUE Gang;LYU Jun(Department of Pharmacy,Rugao Hospital of Traditional Chinese Medicine,Nantong 226500,Jiangsu Province,China;Department of Cardiovascular Medicine,Rugao City,Nantong 226500,Jiangsu Province,China)

机构地区：[1]如皋市中医院药剂科,江苏南通226500 [2]如皋市心血管内科,江苏南通226500

出　　处：《世界临床药物》2025年第2期158-163,共6页World Clinical Drug

基　　金：江苏省中医药科技发展计划项目(MS2021062、MS2023119);南通市自然科学基金;社会民生科技计划指导性项目(MSZ2023106)。

摘　　要：目的 探究瓜薤香丹方联合比索洛尔对稳定型心绞痛(stable angina pectoris,SAP)患者心肌缺血总负荷(total ischemia burden,TIB)及血清抵抗素水平的影响。方法 选择150例于2021年6月至2023年6月本院收治的SAP患者,随机分为西药组(n=75,采用比索洛尔治疗)、中西药联用组(n=75,采用瓜薤香丹方+比索洛尔治疗),比较两组患者的疗效、心功能指标、TIB、血清抵抗素水平及不良反应发生情况。结果 中西药联用组有效率高于西药组,差异有统计学意义(P<0.05)。治疗后,两组左心室射血分数、二尖瓣舒张早期/舒张晚期血流峰值比值均较治疗前升高,且中西药联用组高于西药组(P<0.05),左心室收缩末期容积均降低,且中西药联用组低于西药组(P<0.05);两组TIB及血清抵抗素水平均较治疗前降低,且中西药联用组低于西药组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(8.00% vs.14.67%,P>0.05)。结论 瓜薤香丹方联合比索洛尔能有效改善SAP患者心功能,降低TIB和血清抵抗素水平,且具有良好的安全性。Objective To investigate the effects of Guaxie Xiangdan recipe combined with bisoprolol on total ischemic burden(TIB) and serum resistin level in patients with stable angina pectoris(SAP).Methods A total of 150 SAP patients admitted to our hospital from June 2021 to June 2023 were randomly grouped into the Western medicine group(n=75,treated with bisoprolol) and the combination group(n=75,treated with Guaxie Xiangdan recipe+bisoprolol).The therapeutic efficacy,cardiac function indicators,TIB,serum resistin levels and occurrence of adverse reactions were compared between the two groups.Results The effective rate of the combination group was higher than that of the Western medicine group,and the difference was statistically significant(P<0.05).After treatment,the left ventricular ejection fraction,and early mitral valve diastolic peak blood flow/late mitral valve diastolic peak blood flow increased in both groups compared to before treatment,and the combination group was higher than the Western medicine group(P<0.05).The levels of TIB and serum resistin in both groups decreased compared to before treatment,and the combination group was lower than the Western medicine group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(8.00% vs.14.67%,P>0.05).Conclusion Guaixie Xiangdan recipe combined with bisoprolol can effectively improve the cardiac function of SAP patients,reduce the level of TIB and serum resistin,and has good application safety.

关 键 词：瓜薤香丹方 比索洛尔 稳定型心绞痛 心肌缺血总负荷 血清抵抗素 

分 类 号：R972.4[医药卫生—药品] R541.4[医药卫生—药学]