火药罐对稳定期慢性阻塞性肺疾病肺肾两虚证患者的作用研究  

Effect of medicated cupping on stable chronic obstructive pulmonary disease patients with lung and kidney deficiency syndrome

作　　者：施赛婷 杨建梅[1] 张鸽 徐向前[3] 许笑宇 SHI Saiting;YANG Jianmei;ZHANG ge;XU Xiangqian;XU Xiaoyu(Department of Traditional Chinese Medicine,Shanghai Xuhui Central Hospital,Shanghai 200031,China;Department of Respiratory,Shanghai Xuhui Central Hospital,Shanghai 200031,China;Department of Respiratory,Longhua Hospital of Shanghai University of Chinese medicine,Shanghai 200032,China;Department of Infectious Diseases,Longhua Hospital of Shanghai University of Chinese medicine,Shanghai 200032,China)

机构地区：[1]上海市徐汇区中心医院中医科,上海200031 [2]上海市徐汇区中心医院呼吸科,上海200031 [3]上海中医药大学附属龙华医院呼吸科,上海200032 [4]上海中医药大学附属龙华医院感染科,上海200032

出　　处：《世界临床药物》2025年第2期176-183,共8页World Clinical Drug

基　　金：上海市徐汇区科研项目(SHXH202130);上海中医药大学人文社科科普类(23KFW18);上海中医药大学附属龙华医院爱建基金(AJ062)。

摘　　要：目的 观察火药罐对稳定期慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者肺肾两虚证的临床疗效。方法 选取2022年1月至2024年1月徐汇区中心医院呼吸科门诊及病房稳定期COPD患者66例,根据简单排序随机法分为试验组及对照组,每组33例。试验组在(大椎、定喘、膏盲、肺俞、肾俞及足三里)穴位外涂三子芪白方联合火罐治疗,对照组在以上穴位予单纯火罐治疗,每周一、周四治疗,一周2次,共8周。本研究主要观察第1秒用力呼气容积(forced expiratory volume in one second,FEV_(1))/用力肺活量(forced vital capacity,FVC)的变化值,次要观察指标包括呼气峰流速、FEV_(1)占预计值百分比(FEV_(1)%)、FVC占预计值百分比(FVC%)、C反应蛋白、肿瘤坏死因子(tumor necrosis factor,TNF)-α、COPD评估测试(COPD assessment test,CAT)、6 min步行试验(6-minute walk test,6MWT)及中医证候积分的变化。结果 治疗后,试验组患者的FEV_1/FVC较对照组升高、中医证候积分降低(P<0.05);试验组患者FEV_1%、FVC%、6MWT均较治疗前升高,TNF-α、CAT评分及中医证候积分降低(P<0.05),试验组疗效优于对照组(P<0.05)。结论 火药罐治疗稳定期肺肾两虚证COPD疗效显著,可改善患者肺功能、中医证候,降低炎症反应,提高患者生活质量。Objective To observe the effect of medicated cupping on stable chronic obstructive pulmonary disease(COPD) patients with lung and kidney deficiency syndrome.Methods A total of 66 patients with stable COPD in the outpatient and ward of Respiratory Department of our hospital from January 2022 to January 2024 were selected and divided into experimental group and control group according to the simple sorting random method,with 33 cases in each group.The experimental group was treated with Sanziqi Bai decoction combined with cupping treatment at the acupoints of Dazhui,Dingchuan,Gaomang,Feishu,Shenshu and Zusanli,while the control group was given simple cupping treatment on Mondays and Thursdays,twice a week for 8 weeks.This study mainly observed the changes of forced expiratory volume in one second(FEV_1)/forced vital capacity(FVC).The secondary outcome measures included peak expiratory flow,percentage of predicted value of FEV_(1) (FEV_(1)%),percentage of predicted value of FVC(FVC%),and C-reactive protein,tumor necrosis factor(TNF)-α,COPD assessment test(CAT),6-minute walk test (6MWT) and the change of traditional Chinese medicine(TCM) syndrome score.Results After treatment,the FEV_(1)/FVC of the patients in the experimental group was higher than that of the control group,and the TCM syndrome score was lower(P<0.05).Compared with before treatment,the FEV_(1)%,FVC% and 6MWT of experimental group were increased,while TNF-α,CAT score and TCM syndrome score were decreased(P<0.05),the therapeutic effect of experimental group was better than that of control group(P<0.05).Conclusions Medicated cupping is effective in treating stable COPD patients with lung-kidney deficiency,effectively improving lung function,TCM syndrome score,reducing inflammation and improving quality of life.

关 键 词：火药罐 肺肾两虚证 稳定期慢性阻塞性肺疾病 

分 类 号：R287[医药卫生—中药学] R563.9[医药卫生—中医学]