基于浊毒理论探讨代谢失稳态在溃疡性结肠炎发病中的作用机制  

To explore the mechanism of metabolic instability in the pathogenesis of ulcerative colitis based on the Zhuo Du theory

作　　者：贾雪梅 郭榆西 马虹宇[3] 王杰 赵丹阳 杜朋丽 杜姚[1,2] 李博林 杨倩[1,2] 才艳茹(审校) JIA Xuemei;GUO Yuxi;MA Hongyu;WANG Jie;ZHAO Danyang;DU Pengli;DU Yao;LI Bolin;YANG Qian;CAI Yanru(Department of Spleen and Stomach Diseases,Hebei Hospital of Traditional Chinese Medicine,Shijiazhuang,050011,China;Hebei Provincial Key Laboratory of Zhuodu Pattern;Department of Traditional Chinese Medicine,Hebei Provincial People's Hospital of Traditional Chinese Medicine)

机构地区：[1]河北省中医院脾胃病科,石家庄050011 [2]河北省浊毒证重点实验室 [3]河北省人民医院中医科

出　　处：《中国中西医结合消化杂志》2025年第1期75-80,共6页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：国家中医临床研究基地建设项目[No:国中医药办科技函(2018)131号];国家自然科学基金资助项目(No:82104774);2025年政府资助临床医学优秀人才培养项目(No:ZF2025292);河北省中医药管理局科研计划项目(No:2022032);河北省自然科学基金资助项目(No:H2024423025)。

摘　　要：溃疡性结肠炎患者普遍存在代谢失稳态。代谢失稳态不仅是驱动溃疡性结肠炎发生的原动力,同时也是溃疡性结肠炎致病的必然结果,故改善代谢失稳态具有重要意义。浊毒内蕴是溃疡性结肠炎发病的关键病机,贯穿溃疡性结肠炎发病的整个过程。代谢失稳态所导致的毒性代谢物释放、肠黏膜失完整性、炎症浸润及免疫失衡状态与浊毒内蕴病机表征相契合。化浊解毒法是重塑溃疡性结肠炎代谢稳态的重要治则,通过借助化浊解毒药物清除肠道污秽,重塑肠道代谢环境。本文以代谢失稳态为切入点,探讨溃疡性结肠炎浊毒内蕴的实质,为化浊解毒法治疗溃疡性结肠炎的相关研究提供思路。Metabolic instability is common in patients with ulcerative colitis.Metabolic instability is not only the driving force of ulcerative colitis,but also the inevitable result of ulcerative colitis.Therefore,it is important to improve metabolic instability.Zhuo Du internalization is the key pathogenesis of ulcerative colitis,which runs through the whole process of ulcerative colitis.The release of toxic metabolites,intestinal mucosal integrity,inflammatory infiltration and immune imbalance caused by metabolic instability are consistent with the pathogenesis of Zhuo Du internalization.Turbidity and detoxification method is an important treatment for remolding the metabolic homeostasis of ulcerative colitis,which can remove intestinal filth with the help of turbidity and detoxification drugs,and then,the intestinal metabolic environment can be remade.Based on the metabolic instability,this paper discusses the essence of turbid ulcerative colitis toxin,and provides some ideas for the research on the treatment of ulcerative colitis with turbidity and detoxification method.

关 键 词：溃疡性结肠炎 代谢失稳态 浊毒理论 表征关联 化浊解毒 

分 类 号：R256.3[医药卫生—中医内科学]