石家庄市气态污染物与儿童神经疾病门诊量关系的病例交叉研究  

Case-crossover study on the relationship between gaseous pollutants and outpatient visits for neurological disorders in children in Shijiazhuang

作　　者：梁子越 高旭 陈凤格[1,2] 康慧 张弘 张莹[1,2] LIANG Zi-yue;GAO Xu;CHEN Feng-ge;KANG Hui;ZHANG Hong;ZHANG Ying(Shijiazhuang Center for Disease Control and Prevention,Key Laboratory of Difficult Pathogens in Hebei Province,Shijiazhuang,Hebei 050011,China;不详)

机构地区：[1]石家庄市疾病预防控制中心,河北省疑难病原重点实验室,河北石家庄050011 [2]中国疾病预防控制中心环境与健康研究基地(石家庄),河北石家庄050011 [3]河北医科大学公共卫生学院

出　　处：《现代预防医学》2025年第1期58-62,共5页Modern Preventive Medicine

摘　　要：目的探究石家庄市空气中主要的气态污染物浓度变化对儿童神经系统疾病门诊量的影响。方法收集2013—2021年石家庄市空气污染物数据、气象数据以及儿童神经系统疾病门诊数据,采用基于条件logistic回归模型的病例交叉研究,评估空气中NO_(2)和SO_(2)浓度变化对儿童神经疾病门诊量的影响。结果研究期间空气中NO_(2)浓度每升高10μg/m^(3),儿童神经疾病就诊风险增加1.445%(95%CI:0.980%~1.911%);空气中SO_(2)浓度每升高10μg/m^(3),儿童神经系统疾病就诊风险增加0.408%(95%CI:0.161%~0.655%)。分层分析结果显示,女童以及7~14岁儿童是SO_(2)暴露的敏感人群,冬季气态污染物暴露对儿童神经系统的危害效应更强。结论石家庄市气态污染物暴露可增加儿童神经系统疾病门诊量,不同性别、年龄和季节之间的效应具有差异性。Objective To investigate the impact of changes in the concentrations of major gaseous pollutants in the air of Shijiazhuang on the outpatient visits for neurological disorders in children.Methods Data on air pollutants,meteorological conditions,and outpatient visits for pediatric neurological disorders from 2013 to 2021 in Shijiazhuang were collected.A case-crossover study based on conditional logistic regression models was employed to assess the effects of changes in NO_(2) and SO_(2) concentrations on the outpatient visits for neurological disorders in children.Results During the study period,for every increase of 10μg/m^(3) in NO_(2) concentration,the risk of outpatient visits for neurological disorders in children increased by 1.445%(95%CI:0.980%-1.911%);for every increase of 10μg/m3 in SO_(2) concentration,the risk increased by 0.408%(95%CI:0.161%-0.655%).Stratified analysis revealed that girls and children aged 7 to 14 years were sensitive populations to SO_(2) exposure,and the harmful effects of gaseous pollutants on the neurological system of children were stronger in winter.Conclusion Exposure to gaseous pollutants in Shijiazhuang is associated with an increase in outpatient visits for neurological disorders in children,with variations in effects observed based on gender,age,and season.

关 键 词：病例交叉研究 气态污染物 门诊量 神经系统疾病 儿童 

分 类 号：R122[医药卫生—环境卫生学] R179[医药卫生—公共卫生与预防医学]