中国男男性行为者HIV暴露后预防用药接受意愿相关因素的Meta分析  

Meta-analysis of factors influencing willingness to accept HIV post-exposure prophylaxis among Chinese men who have sex with men

作　　者：何艳 楚鑫[2] 李娜娜 郑敏瑶 饶佳[3] HE Yan;CHU Xin;LI Na-na;ZHENG Min-yao;RAO Jia(School of Nursing,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610103,China;不详)

机构地区：[1]成都中医药大学护理学院,四川成都610103 [2]成都中医药大学附属医院,四川成都610103 [3]凉山彝族自治州第一人民医院

出　　处：《现代预防医学》2025年第1期167-173,共7页Modern Preventive Medicine

基　　金：凉山州技术研究开发与推广应用项目(17YYJS0014)。

摘　　要：目的 系统评价中国男男性行为(men who have sex with men, MSM)者HIV暴露后预防用药接受意愿的影响因素。方法 在Pub Med、Web of Science、The Cochrane Library、EMbase、中国知网、维普、万方和CBM数据库中,检索2024年9月5日前MSM HIV暴露后预防用药接受意愿相关因素的研究,采用Rev Man 5.3软件分别对纳入的影响因素进行meta分析。结果 共纳入26篇文献,调查人数31 600例,提取20个影响因素。Meta分析结果显示:年龄≤30岁(OR=1.65,95%CI:1.31~2.07)、月收入5 000~10 000元(OR=1.96,95%CI:1.51~2.55)、月收入>10 000元(OR=1.98,95%CI:1.03~3.80)、HIV阳性性伴侣(OR=2.47,95%CI:1.21~5.05)、多个性伴侣(OR=2.51,95%CI:1.90~3.32)、网约性伴侣(OR=2.03,95%CI:1.55~2.65)、知晓HIV相关知识(OR=2.33,95%CI:1.81~3.00)、知晓暴露后预防(post-exposure prevention,PEP)相关知识(OR=2.17,95%CI:1.33~3.54)、咨询过PEP(OR=26.09,95%CI:5.34~127.41)、使用性毒品(OR=2.01,95%CI:1.18~3.42)、使用安全套(OR=2.10,95%CI:1.66~2.66)、HIV检测≥2次/年(OR=2.33,95%CI:1.80~3.02)、性传播感染(OR=1.93,95%CI:1.52~2.45)、商业性行为(OR=3.21,95%CI:1.95~5.30)、同伴性教育(OR=1.60,95%CI:1.23~2.08)是MSM者HIV暴露后预防用药接受意愿的促进因素;同性恋(OR=0.34,95%CI:0.23~0.49)是其阻碍因素。结论 我国MSM者HIV暴露后预防用药接受意愿的影响因素较多且复杂,未来应加强对HIV和PEP相关知识的宣传和推广,降低MSM人群中HIV发病率。Objective To systematically evaluate the factors influencing the willingness to accept HIV post-exposure prophylaxis(PEP)among men who have sex with men(MSM)in China.Methods Studies related to the willingness to accept HIV PEP among MSM published before September 5,2024,were searched in PubMed,Web of Science,The Cochrane Library,EM base,China National Knowledge Infrastructure(CNKI),Wan fang,VIP,and CBM databases.Meta-analysis of the included factors was conducted using Rev Man 5.3 software.Results A total of 26 studies were included,with 31600 participants,and 20 influencing factors were extracted.The results of the meta-analysis indicated that factors promoting the willingness to accept HIV PEP included:age≤30 years(OR=1.65,95%CI:1.31-2.07),monthly income of 5000-10000 yuan(OR=1.96,95%CI:1.51-2.55),monthly income>10000 yuan(OR=1.98,95%CI:1.03-3.80),having an HIV-positive sexual partner(OR=2.47,95%CI:1.21-5.05),multiple sexual partners(OR=2.51,95%CI:1.90-3.32),online sexual partners(OR=2.03,95%CI:1.55-2.65),awareness of HIV-related knowledge(OR=2.33,95%CI:1.81-3.00),awareness of PEP-related knowledge(OR=2.17,95%CI:1.33-3.54),having consulted about PEP(OR=26.09,95%CI:5.34-127.41),use of recreational drugs(OR=2.01,95%CI:1.18-3.42),condom use(OR=2.10,95%CI:1.66-2.66),HIV testing at least twice a year(OR=2.33,95%CI:1.80-3.02),sexually transmitted infections(OR=1.93,95%CI:1.52-2.45),commercial sex work(OR=3.21,95%CI:1.95-5.30),and peer education(OR=1.60,95%CI:1.23-2.08).The factor hindering willingness was identified as being gay(OR=0.34,95%CI:0.23-0.49).Conclusion The factors influencing the willingness to accept HIV PEP among MSM in China are various and complex.Future efforts should focus on enhancing the promotion and dissemination of knowledge related to HIV and PEP to reduce the incidence of HIV within the MSM population.

关 键 词：男男性行为 暴露后预防 影响因素 中国 META分析 

分 类 号：R512.91[医药卫生—内科学]