北京市汉族不同血管紧张素转化酶基因I/D表型的中老年人群血脂水平与动脉硬度的相关性  

The correlation between blood lipid levels and arterial stiffness in middle-aged and elderly Han Chinese with angiotensin-converting enzyme gene I/D polymorphism in Beijing

作　　者：金宗学 吕媛媛 赵丽 任世琪[2,3] 於来康 Jin Zongxue;Lyu Yuanyuan;Zhao Li;Ren Shiqi;Yu Laikang(Trauma Treatment Center,Peking University People's Hospital,Key Laboratory of Trauma Treatment and Neural Regeneration(Peking University),National Center for Trauma Medicine,Beijing 100044,China;Beijing Key Laboratory of Sports Performance and Skill Assessment,Beijing Sport University,Beijing 100084,China;China Institute of Sport and Health Science,Beijing Sport University,Beijing 100084,China;Department of Exercise Physiology,Beijing Sport University,Beijing 100084,China;Department of Strength and Conditioning Assessment and Monitoring,Beijing Sport University,Beijing 100084,China)

机构地区：[1]北京大学人民医院创伤救治中心创伤救治与神经再生教育部重点实验室(北京大学)国家创伤医学中心,北京100044 [2]北京体育大学北京市运动机能评定与技术分析重点实验室,北京100084 [3]北京体育大学中国运动与健康研究院,北京100084 [4]北京体育大学运动生理教研室,北京100084 [5]北京体育大学体能测评与监控教研室,北京100084

出　　处：《中华老年医学杂志》2025年第3期346-352,共7页Chinese Journal of Geriatrics

基　　金：国家重点研发计划(2022YFC3600201);中央高校基本科研业务费专项资金资助项目(2024JNPD004,2024YJSY005)。

摘　　要：目的探究北京市汉族不同血管紧张素转化酶(angiotensin-converting enzyme,ACE)基因I/D表型的中老年人群血脂水平与动脉硬度的相关性。方法横断面调查研究,2022年5—8月招募北京市海淀区45岁及以上常住汉族人群进行调查,依据纳入和排除标准,最终纳入356例研究对象,其中男性100例(28.09%)、女性256例(71.91%)。根据世界卫生组织提出的人群划分标准,将受试者分为中年组253例[45~59岁,中位年龄52.5(49.0,56.0)岁]和老年组103例[60~89岁,中位年龄63.0(61.0,65.0)岁]。对受试者进行ACE基因分型、血脂和肱-踝动脉脉搏波传导速度(brachial-ankle pulse wave velocity,baPWV)检测,血脂指标包括三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)。结果中年组DD型和ID/Ⅱ型人群血浆TC、TG和HDL-C水平差异均无统计学意义(均P>0.05);老年组DD型和ID/Ⅱ型人群血浆TC、TG和HDL-C水平差异均无统计学意义(均P>0.05);中年组DD型人群的血浆LDL-C水平高于ID/Ⅱ型人群(Z=-2.483,P=0.013),而老年组两种表型人群的血浆LDL-C水平差异无统计学意义(Z=-0.935,P=0.350)。中年组和老年组DD型和ID/Ⅱ型人群baPWV差异均无统计学意义(Z=-0.104、-1.490,P=0.917、0.136)。老年组DD型人群血浆TG水平与baPWV呈正相关(r=0.590,P=0.016);中年组ID/Ⅱ型人群血浆TG水平与baPWV呈正相关(r=0.158,P=0.019),血浆HDL-C水平与baPWV呈负相关(r=-0.174,P=0.009)。结论在具有不同ACE基因I/D表型的中老年人群中,影响其动脉硬度的血脂敏感指标存在差异,ID/Ⅱ型中年人群动脉硬度的血脂敏感指标为高TG和低HDL-C水平,DD型老年人群动脉硬度的血脂敏感指标为高TG水平,这可为不同人群更精准地管控血脂,保持心血管健康,从而降低心血管疾病发生率提供了依据。ObjectiveTo investigate the correlation between blood lipid levels and arterial stiffness in middle-aged and elderly Han Chinese individuals with angiotensin-converting enzyme(ACE)gene I/D polymorphism in Beijing.MethodsThis was a cross-sectional study.The Han Chinese residents,aged 45 years and above,from Haidian District of Beijing,were recruited for the survey from May to August 2022.Based on the inclusion and exclusion criteria,356 subjects were included,of which 100(28.09%)were male and 256(71.91%)were female.According to the population division criteria proposed by the World Health Organization,the subjects were divided into 253 cases in the middle-aged group[45-59 years old,median age 52.5(49.0,56.0)years]and 103 cases in the elderly group[60-89 years old,median age 63.0(61.0,65.0)years].Subjects were tested for ACE genotyping,lipids and brachial-ankle pulse wave velocity(baPWV).Lipid indices included triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C).ResultsIn the middle-aged group,there were no significant differences in plasma levels of TC,TG and HDL-C between individuals with the DD genotype and those with the ID/Ⅱgenotype(all P>0.05).Similarly,in the elderly group,no significant differences were observed in plasma TC,TG,and HDL-C levels between individuals with the DD genotype and those with the ID/Ⅱgenotype(all P>0.05).In the middle-aged group,plasma LDL-C levels were significantly higher in the DD phenotype than in the ID/Ⅱphenotype(Z=-2.483,P=0.013),while there was no significant difference in plasma LDL-C levels between the two phenotypes in the elderly group(Z=-0.935,P=0.350).There were no significant differences in baPWV between the DD and ID/Ⅱphenotypes in both the middle-aged and elderly groups(Z=-0.104,-1.490,P=0.917,0.136).In the elderly group,plasma TG levels were positively correlated with baPWV in the DD phenotype(r=0.590,P=0.016).In the middle-aged group,plasma TG levels were positively correlated with

关 键 词：血管紧张素转化酶 基因多态性 血脂 动脉僵硬度 

分 类 号：R54[医药卫生—心血管疾病]