自动在线固相萃取与超高效液相色谱三重四极杆质谱联用分析污水中的毒品  

Detection of illicit drugs in sewage by automatic online solid extraction combined with ultra-high performance liquid chromatography triple quadrupole mass spectrometry

作　　者：李堪 刘佳琪 杜明荦 徐若沦 LI Kan;LIU Jiaqi;DU Mingluo;XU Ruolun(Anti-Drug Technology Center of Guangdong Province,Guangzhou 510000,China;Shimadzu(China)Co.,Ltd.,Guangzhou 510000,China)

机构地区：[1]广东省毒品实验技术中心,广州510000 [2]岛津企业管理(中国)有限公司,广州510000

出　　处：《分析试验室》2025年第2期264-272,共9页Chinese Journal of Analysis Laboratory

基　　金：广东省精神活性物质监测与安全重点实验室项目(2020B121201007)资助。

摘　　要：建立了自动在线固相萃取(AOE)与超高效液相色谱三重四极杆质谱联用(UPLC-MS/MS)检测生活污水中13种常见毒品及代谢物和1种人口标记物的一次进样分析方法。该方法将样品净化、富集和分析过程高度集成,在17 min内完成14种物质的分析测定,采用内标法定量。该方法线性良好,相关系数均在0.998以上;各组分的回收率和相对标准偏差(RSDs)分别在88.0%~120.1%和0.3%~3.8%之间,基质效应不影响分析结果的准确性。本文的大体积进样AOE系统分析方法的检测结果与常规离线分析方法结果无显著区别(P>0.05),可用于分析生活污水中的常见毒品。A single-injection method was established for the detection of 13 common illicit drugs and metabolites,and one population marker in domestic sewage by an automatic online extraction(AOE)system combined with ultra-high performance liquid chromatography triple quadrupole mass spectrometry(UPLC-MS/MS).In this method,the process of sample purification,enrichment and detection was highly integrated,and the detection of 14 substances was completed within 17 min.The internal standard method was used for quantification.The method had a good linearity,and the correlation coefficients were greater than 0.998.The recoveries and relative standard deviations(RSDs)were 88.0%-120.1%and 0.3%-3.8%,respectively.Moreover,the matrix effects do not affect the accuracy of the results.There is no significant difference between the results of the large-volume sampling AOE system and the conventional off-line analysis method(P>0.05),and this method can be used to analyze common illicit drugs in domestic sewage.

关 键 词：自动在线固相萃取系统 超高效液相色谱三重四极杆质谱联用 毒品分析 污水 

分 类 号：O657.63[理学—分析化学] X832[理学—化学]