舍曲林联合重复经颅磁刺激治疗青少年强迫症的临床疗效  

Clinical Efficacy of Sertraline combined with Repeated Transcranial Magnetic Stimulation in the Treatment of Adolescent Obsessive-Compulsive Disorder

作　　者：王彦辉[1] 谷丛欣 刘海凤[1] 苏鹏 眭朝平 WANG Yanhui;GU Congxin;LIU Haifeng(Sixth Department of Psychiatry,Shijiazhuang Eighth Hospital,Shijiazhuang 050070,China)

机构地区：[1]石家庄市第八医院精神六科,石家庄050070

出　　处：《国际精神病学杂志》2025年第1期132-135,共4页Journal Of International Psychiatry

摘　　要：目的 探讨舍曲林联合重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗青少年强迫症的临床疗效。方法 选择2020年10月~2023年6月150例青少年强迫症患者,数字表法随机分组。对照组74例采用舍曲林治疗,观察组76例在对照组基础上采用rTMS治疗。比较干预前后焦虑、强迫症状、血清相关指标以及不良反应发生情况。结果 两组治疗后耶鲁-布朗强迫量表(Yale-Brown obsessive compulsive scale,Y-BOCS)、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评分均显著降低,且治疗后观察组各项评分均低于对照组,观察组治疗前后差值显著高于对照组(P<0.05);两组治疗后血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)水平、5-羟色胺(5-hydroxytryptamine,5-HT)均显著升高,且治疗后观察组各项指标均高于对照组,观察组治疗前后差值显著高于对照组(P<0.05);两组治疗2周、6周时副反应量表评分差异无统计学意义(P>0.05)。结论 舍曲林联合rTMS治疗青少年强迫症能够提升临床疗效,改善血清指标水平,治疗安全有效。Objective To explore the clinical efficacy of sertraline combined with repetitive transcranial magnetic stimulation(rTMS)in the treatment of adolescent obsessive-compulsive disorder.Methods A total of 150 adolescent obsessive-compulsive disorder patients from October 2020 to June 2023 were selected,and they were randomly grouped using a numerical table method.74 cases in the control group were treated with sertraline,while 76 cases in the observation group were treated with rTMS on the basis of the control group.The anxiety,obsessive-compulsive symptoms,serum related indicators,and incidence of adverse reactions before and after intervention were compared.Results After treatment,the scores of the Yale Brown Obsessive Compulsive Scale(Y-BOCS)and Hamilton Anxiety Scale(HAMA)were significantly reduced in both groups,and the scores of the observation group were lower than those of the control group,the difference before and after treatment in observation group was significantly higher than that in control group(P<0.05).After treatment,the serum levels of brain-derived neurotrophic factor(BDNF)and 5-hydroxytryptamine(5-HT)were significantly increased in both groups,and all indicators in the observation group were higher than those in the control group(P<0.05),the difference before and after treatment in observation group was significantly higher than that in control group(P<0.05).There was no statistically significant difference in the scores of the adverse reaction scale between the two groups at 2 and 6 weeks of treatment(P>0.05).Conclusion The combination of sertraline and rTMS in the treatment of adolescent obsessive-compulsive disorder can enhance clinical efficacy,improve serum indicator levels,and ensure safe and effective treatment.

关 键 词：舍曲林 重复经颅磁刺激 青少年强迫症 

分 类 号：R749.05[医药卫生—神经病学与精神病学]