线粒体自噬与免疫稳态、肠道健康的互联机制及其调控研究进展  

Research Progress on Interconnected Mechanisms of Mitophagy with Immune Homeostasis and Gut Health and Its Regulation

作　　者：杨攀 方梦瑶 田志梅 余苗 YANG Pan;FANG Mengyao;TIAN Zhimei;YU Miao(Guangdong Engineering Technology Research Center of Animal Meat quality and Safety Control and Evaluation,Guangdong Public Laboratory of Animal Breeding and Nutrition,State Key Laboratory of Swine and Poultry Breeding,Key Laboratory of Animal Nutrition and Feed Science in South China of Ministry of Agriculture and Rural Affairs,Institute of Animal Science,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China)

机构地区：[1]广东省农业科学院动物科学研究所,农业农村部华南动物营养与饲料重点实验室,猪禽种业全国重点实验室,广东省畜禽育种与营养研究重点实验室,广东省畜禽肉品质量安全控制与评定工程技术研究中心,广州510640

出　　处：《动物营养学报》2025年第3期1424-1435,共12页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金项目(32372928);广东省基础与应用基础研究基金项目(2024A1515030187);科技创新战略专项(R2023YJ-YB3006,R2023PY-JX015,R2020YJ-YB2002);广东省乡村振兴战略专项资金(2023TS-3,2023KJ465)。

摘　　要：线粒体自噬是细胞内维持线粒体稳态的重要机制。近年来,线粒体自噬因其与免疫稳态和肠道健康的密切关联,已成为动物营养学研究的一个热点。许多调控线粒体自噬分子机制也已被报道,这为进一步理解线粒体自噬发生过程、维持线粒体功能与细胞内稳态提供了新手段。在本文中,综述了有关于线粒体自噬分子机制的前沿报道,讨论了线粒体自噬的作用及其与免疫稳态、肠道健康之间的互联机制,汇总了当前研究较多的化合物调控自噬的研究报道,旨在为以线粒体为中心的营养调控机制研究提供参考。Mitophagy is a crucial mechanism within cells for maintaining mitochondrial homeostasis.In recent years,due to its close association with immune homeostasis and gut health,mitophagy has become a focal point in animal nutrition research.Numerous molecular mechanisms regulating mitophagy have been reported,providing new approaches to better understand the process of mitophagy,its role in maintaining mitochondrial function,and overall cellular homeostasis.This paper reviewed the cutting-edge research on the molecular mechanisms of mitophagy,discussed its role and the interconnected pathways between mitophagy and immune homeostasis,gut health,and summarized the current studies on compounds that regulated autophagy.The aim is to offer insights for further research on mitochondria-centered regulatory mechanisms.

关 键 词：线粒体自噬 分子机制 免疫稳态 肠道健康 分子调控 

分 类 号：S852.2[农业科学—基础兽医学]