巨噬细胞极化机理及益生菌介导其极化改善肠道健康的研究进展  

Research Progress on Mechanism of Macrophage Polarization and Improvement of Intestinal Health Mediated by Probiotics through Macrophage Polarization

作　　者：梁坤 秦小霞 杨玲媛[1,2,3] 黄兴国 LIANG Kun;QIN Xiaoxia;YANG Lingyuan;HUANG Xingguo(College of Animal Science and Technology,Hunan Agricultural University,Changsha 410128,China;Key Laboratory of Livestock and Poultry Resources(Pig)Evaluation and Utilization,Ministry of Agriculture and Rural Affairs,Changsha 410128,China;Yuelushan Laboratory,Changsha 410128,China)

机构地区：[1]湖南农业大学动物科学技术学院,长沙410128 [2]农业农村部畜禽资源(猪)评价利用重点实验室,长沙410128 [3]岳麓山实验室,长沙410128

出　　处：《动物营养学报》2025年第3期1470-1479,共10页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：湖南省自然科学基金重点项目(2024JJ3020);湖南省教育厅科学研究重点项目(24A0153)。

摘　　要：益生菌作为优质的“替抗品”,在畜禽肠道健康中发挥着重要作用,提高了畜禽生产水平。作为一种先天免疫细胞,巨噬细胞在吞噬、炎症等反应中发挥着重要作用。不同的巨噬细胞表型具有不同的生物学功能,并受到不同因素和机制的调节。研究发现,益生菌能够介导巨噬细胞极化、保护肠道屏障、缓解肠道炎症、维持肠道内环境稳态。因此,本文就巨噬细胞极化机制和益生菌介导巨噬细胞极化改善宿主肠道健康展开论述,以期为未来益生菌调控畜禽肠道健康的研究提供参考。Probiotics,serving as high-quality alternatives to antibiotics,play a crucial role in promoting intestinal health and enhancing production performance in livestock and poultry.Macrophages,as innate immune cells,are pivotal in phagocytosis,inflammation,and other immune responses.Distinct macrophage phenotypes exhibit various biological functions and are regulated by different factors and mechanisms.Studies have shown that probiotics can mediate macrophage polarization,protect intestinal barriers,alleviate intestinal inflammation,and maintain intestinal homeostasis.Therefore,this paper discusses the mechanisms of macrophage polarization and the improvement of host intestinal health through probiotic-mediated macrophage polarization,aiming to provide a reference for future research on the regulation of intestinal health in livestock and poultry using probiotics.

关 键 词：益生菌 巨噬细胞 极化 肠道健康 免疫 

分 类 号：S811.2[农业科学—畜牧学]