富马酸和肉桂醛及其联合添加对断奶仔猪生长性能、血清生化和抗氧化指标以及肠道炎症反应的影响  

Effects of Fumaric Acid and Cinnamic Aldehyde and Their Combination on Growth Performance,Serum Biochemical and Antioxidant Indices and Intestinal Inflammatory Response of Weaned Piglets

作　　者：刘禹彤 杨冠华 王璐瑶 马欣怡 乔家运 李海花 LIU Yutong;YANG Guanhua;WANG Luyao;MA Xinyi;QIAO Jiayun;LI Haihua(Tianjin Key Laboratory of Conservation and Utilization of Animal Diversity,College of Life Sciences,Tianjin Normal University,Tianjin 300387,China;Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry,College of Animal Science and Veterinary Medicine,Tianjin Agricultural University,Tianjin 300384,China)

机构地区：[1]天津师范大学生命科学学院,天津市动物多样性保护与利用重点实验室,天津300387 [2]天津农学院动物科学与动物医学学院,天津市农业动物繁育与健康养殖重点实验室,天津300384

出　　处：《动物营养学报》2025年第3期1575-1584,共10页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：天津市“131”创新型人才团队(20180338)。

摘　　要：本试验旨在探究富马酸和肉桂醛及其联合添加对断奶仔猪生长性能、血清生化和抗氧化指标以及肠道炎症反应的影响。选用初始体重为(7.79±0.48)kg的28日龄“杜×长×大”杂交断奶仔猪72头(公母各占1/2),随机分为4组,每组6个重复,每个重复3头猪,单栏饲养。对照组(CON组)饲喂基础饲粮,试验组分别饲喂在基础饲粮的基础上添加600 mg/kg富马酸(富马酸组,FA组)、400 mg/kg肉桂醛(肉桂醛组,CA组)和600 mg/kg富马酸+400 mg/kg肉桂醛(联合添加组,FC组)的饲粮。试验期28 d。试验结束当天08:00,每组抽取6头仔猪腹腔内注射200μg/kg BW脂多糖(LPS)。结果表明:1)与CON组相比,各试验组断奶仔猪末重、平均日增重(ADG)和平均日采食量(ADFI)均显著提高(P<0.05),料重比(F/G)均显著降低(P<0.05)。同时,FA组和FC组末重和ADG显著高于CA组(P<0.05)。2)与CON组相比,CA组和FC组断奶仔猪血清丙二醛(MDA)含量显著降低(P<0.05),血清过氧化氢酶(CAT)活性显著提高(P<0.05)。同时,FC组血清MDA含量显著低于FA组和CA组(P<0.05),血清CAT活性显著高于FA组和CA组(P<0.05)。3)与CON组相比,各试验组断奶仔猪血清肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)含量均显著降低(P<0.05)。同时,CA组和FC组血清TNF-α含量显著低于FA组(P<0.05)。4)与CON+LPS组相比,各试验组断奶仔猪空肠TNF-α和IL-6含量均显著降低(P<0.05),空肠白细胞介素-10(IL-10)含量均显著提高(P<0.05);FA+LPS组空肠转化生长因子-β(TGF-β)含量显著提高(P<0.05)。同时,FC+LPS组空肠TNF-α和IL-6含量显著低于FA+LPS组和CA+LPS组(P<0.05)。5)与CON+LPS组相比,各试验组断奶仔猪空肠Toll样受体4(TLR4)、核因子-κB(NF-κB)、TNF-α和IL-6 mRNA相对表达量均显著降低(P<0.05),空肠TGF-β和IL-10 mRNA相对表达量均显著提高(P<0.05)。综上所述,饲粮单独添加富马酸和肉桂醛或两者联合添加可以提高断奶仔猪生长性能、抗氧化功能和抗炎�This experiment was conducted to investigate the effects of fumaric acid and cinnamic aldehyde and their combination on growth performance,serum biochemical and antioxidant indices and intestinal inflammatory response of weaned piglets.A total of 72“Duroc×Landrace×Yorkshine”crossbred weaned piglets(half male and half female)of 28-day-old with an initial body weight of(7.79±0.48)kg were randomly divided into 4 groups with 6 replicates per group and 3 pigs per replicate,and raised in individual pens.Piglets in the control group(CON group)were fed a basal diet,and others in the experimental groups were fed the basal diet supplemented with 600 mg/kg fumaric acid(FA group),400 mg/kg cinnamic aldehyde(CA group)and 600 mg/kg fumaric acid+400 mg/kg cinnamic aldehyde(combined supplemental group,FC group),respectively.The experiment lasted for 28 days.At 08:00 on the day after the experiment,6 piglets in each group were injected with 200μg/kg BW lipopolysaccharide(LPS)intraperitoneally.The results showed as follows:1)compared with CON group,the final body weight,average daily gain(ADG)and average daily feed intake(ADFI)of weaned piglets in experimental groups were significantly increased(P<0.05),and the ratio of feed to gain(F/G)was significantly decreased(P<0.05).Meanwhile,the final body weight and ADG in FA and FC groups were significantly higher than those in CA group(P<0.05).2)Compared with CON group,the serum malondialdehyde(MDA)content of weaned piglets in CA and FC groups was significantly decreased(P<0.05),and the serum catalase(CAT)activity was significantly increased(P<0.05).Meanwhile,the serum MDA content in FC group was significantly lower than that in FA and CA groups(P<0.05),and the serum CAT activity was significantly higher than that in FA and CA groups(P<0.05).3)Compared with CON group,the serum contents of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)of weaned piglets in experimental groups were significantly decreased(P<0.05).Meanwhile,the serum TNF-α content in CA and FC groups was si

关 键 词：富马酸 肉桂醛 断奶仔猪 生长性能 抗氧化 炎症反应 

分 类 号：S816.7[农业科学—饲料科学]