超声评估不同病理分期老年卵巢癌患者血流动力学变化及其对预后的预测价值  

Evaluation of hemodynamic changes in elderly ovarian cancer patients with different pathological stages and predicting prognosis by ultrasound

作　　者：郭琳琳 王文 王海燕[2] GUO Linlin;WANG Wen;WANG Haiyan(First Clinical Medical College,Ningxia Medical University,Yinchuan 750004,China;Department of Functional Examinations,General Hospital of Ningxia Medical University,Yinchuan 750004,China;Department of Ultrasound,General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学第一临床医学院,宁夏银川750004 [2]宁夏医科大学总医院妇产中心功能检查部,宁夏银川750004 [3]宁夏医科大学总医院心脑血管病医院超声科,宁夏银川750004

出　　处：《临床超声医学杂志》2025年第3期193-197,共5页Journal of Clinical Ultrasound in Medicine

基　　金：国家自然科学基金项目(8226070416);宁夏回族自治区科技惠民专项项目(2023CMG03025)。

摘　　要：目的应用频谱多普勒和三维超声容积成像评估不同病理分期老年卵巢癌患者血流动力学变化,探讨其对预后的预测价值。方法选取我院收治的150例老年卵巢癌患者,根据肿瘤病理分期分为Ⅰ期组(27例)、Ⅱ期组(32例)和Ⅲ~Ⅳ期组(91例),均行频谱多普勒和经阴道三维超声容积成像检查分别获取阻力指数(RI)、搏动指数(PI)、收缩期峰值流速(PSV)及血管指数(VI),比较各组入院时上述参数的差异。所有患者随访3~39个月,根据预后情况分为存活者118例和死亡者32例,比较两者入院时RI、PI、PSV、VI的差异。绘制受试者工作特征(ROC)曲线分析各参数单独及联合应用预测老年卵巢癌患者预后的诊断效能。结果各组RI、PI、PSV、VI比较差异均有统计学意义(均P<0.05)。Ⅲ~Ⅳ期组RI、PI低于Ⅰ、Ⅱ期组,VI高于Ⅰ、Ⅱ期组,PSV高于Ⅱ期组;Ⅱ期组RI、PI低于Ⅰ期组,PSV高于Ⅰ期组,差异均有统计学意义(均P<0.05)。死亡者RI、PI低于存活者,PSV、VI高于存活者,差异均有统计学意义(均P<0.001)。ROC曲线分析显示,RI、PI、PSV、VI单独及联合应用预测老年卵巢癌患者预后的曲线下面积分别为0.750、0.757、0.790、0.765、0.810。结论频谱多普勒和三维超声容积成像均可较好地评估不同病理分期老年卵巢癌患者的血流动力学变化,对患者预后具有一定的预测价值。Objective To evaluate hemodynamic changes in elderly ovarian cancer patients with different pathological stages by spectral Doppler and three-dimensional ultrasound volume imaging,and to explore its prognostic value.Methods A total of 150 elderly ovarian cancer patients were classified into stageⅠ(27 cases),stageⅡ(32 cases),and stageⅢ~Ⅳ(91 cases)groups according to pathological staging.Spectral Doppler and transvaginal three-dimensional ultrasound volume imaging were performed to obtain the resistance index(RI),pulsatility index(PI),peak systolic velocity(PSV),and vascular index(VI),the differences of above parameters among groups were compared.Patients were followed for 3~39 months and divided into survival patients(118 cases)and death patients(32 cases),the difference in RI,PI,PSV,and VI between two items were compared.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic efficacy of individual and combined parameters in predicting prognosis.Results Significant differences were observed in RI,PI,PSV,and VI among groups(all P<0.05).The stageⅢ~Ⅳgroup had lower RI and PI but higher VI compared to stageⅠ,Ⅱgroups(all P<0.05).The death patients showed significantly lower RI and PI but higher PSV and VI than those in the survival patients(all P<0.001).ROC curve analysis showed that the area under the curve of RI,PI,PSV,VI,and combined parameters in predicting prognosis were 0.750,0.757,0.790,0.765,0.810,respectively.Conclusion Spectral Doppler and three-dimensional ultrasound volume imaging both can effectively evaluate hemodynamic changes and demonstrates significant prognostic value in elderly ovarian cancer patients.

关 键 词：超声检查 多普勒 频谱 三维容积成像 卵巢癌 血流动力学 预后 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.3[医药卫生—诊断学]