应变式弹性成像诊断三阴性乳腺癌的临床价值  

Clinical value of strain elastography in the diagnosis of triple-negative breast cancer

作　　者：王蓉[1] 刘瑜[2] 杨广祥 贾罗好 WANG Rong;LIU Yu;YANG Guangxiang;JIA Luohao(Department of Ultrasound,Health Examination Center,Affiliated Zhongshan Hospital of Dalian University,Dalian 116000,China;Department of Ultrasound,Affiliated Zhongshan Hospital of Dalian University,Dalian 116000,China;Department of Ultrasound,Chashan Hospital Affiliated to Guangdong Medical University,Dongguan 512049,China)

机构地区：[1]大连大学附属中山医院体检中心超声科,辽宁大连116000 [2]大连大学附属中山医院超声科,辽宁大连116000 [3]广东医科大学附属茶山医院超声科,广东东莞512049

出　　处：《临床超声医学杂志》2025年第3期238-242,共5页Journal of Clinical Ultrasound in Medicine

摘　　要：目的探讨应变式弹性成像在三阴性乳腺癌(TNBC)诊断中的临床价值,分析超声弹性成像(UE)评分、应变率比值(SR)与微血管密度(MVD)的关系。方法选取我院收治的150例乳腺癌患者,其中TNBC组29例和非TNBC组121例,均行应变式弹性成像检查获取UE评分和SR,病理检查获取MVD;比较两组上述检查结果的差异。采用Pearson相关分析法分析TNBC患者UE评分、SR与MVD的关系。绘制受试者工作特征(ROC)曲线分析UE评分、SR及其联合应用对TNBC的诊断效能。结果TNBC组和非TNBC组UE评分、SR分别为(4.35±0.18)分、3.57±0.28和(4.19±0.13)分、3.36±0.15,差异均有统计学意义(均P<0.05)。TNBC组MVD为(46.75±11.23)个/mm^(2),非TNBC组为(39.28±10.05)个/mm^(2),差异有统计学意义(P<0.05)。相关性分析显示,TNBC患者UE评分、SR与MVD均呈正相关(r=0.738、0.692,均P<0.05)。ROC曲线分析显示,UE评分、SR诊断TNBC的曲线下面积分别为0.791、0.734,二者联合应用的曲线下面积为0.877,与单独应用比较差异均有统计学意义(Z=5.372、3.885,均P<0.001)。结论应变式弹性成像在TNBC诊断中具有较好的临床价值,且UE评分、SR与MVD均呈正相关。Objective To investigate the clinical value of strain elastography in the diagnosis of triple-negative breast cancer(TNBC),and to analyze the relationship between ultrasound elastography(UE)score,strain ratio(SR)and microvessel density(MVD).Methods A total of 150 breast cancer patients in our hospital were enrolled and divided into TNBC group(29 cases)and non-TNBC group(121 cases).Both groups underwent strain elastography to obtain UE scores and SR,and MVD was obtained by pathological examination.The differences in these parameters between the two groups were compared.Pearson correlation analysis was used to analyze the relationship between UE score,SR and MVD in TNBC patients.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic performance of UE score,SR,and their combined application for TNBC.Results The UE score and SR in the TNBC group were(4.35±0.18)points and 3.57±0.28,respectively,while those in the non-TNBC group were(4.19±0.13)points and 3.36±0.15,respectively,with statistically significant differences(both P<0.05).The MVD in the TNBC group was(46.75±11.23)vessels/mm^(2),significantly higher than that in the non-TNBC group(39.28±10.05)vessels/mm^(2),the differences was statistically significant(P<0.05).Correlation analysis showed that UE score and SR were positively correlated with MVD in TNBC patients(r=0.738,0.692,both P<0.05).ROC curve analysis showed that the area under the curve(AUC)for UE score and SR in diagnosing TNBC were 0.791 and 0.734,respectively.The combined AUC of UE score and SR was 0.877,which were significantly higher than that of each parameter alone(Z=5.372,3.885,both P<0.001).Conclusion Strain elastography has significant clinical value in the diagnosis of TNBC,and both UE score and SR are positively correlated with MVD.

关 键 词：超声弹性成像 弹性评分 应变率比值 三阴性乳腺癌 微血管密度 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.9[医药卫生—诊断学]