热性感染相关性癫痫综合征  

Febrile infection-related epilepsy

作　　者：吴晔[1] 桑田[1] 管巧 Wu Ye;Sang Tian;Guan Qian(Department of Pediatrics,Children’sMedical Center,Peking University First Hospital)

机构地区：[1]北京大学第一医院儿童医学中心,北京102627

出　　处：《重庆医科大学学报》2025年第3期275-279,共5页Journal of Chongqing Medical University

摘　　要：热性感染相关性癫痫综合征(febrile infection-related epilepsy syndrome,FIRES)是一种发生在既往健康的儿童和青少年的炎症相关急性脑病,以热性感染后出现的超级难治性癫痫持续状态为临床特征,多数预后不良。近年来随着对该病认识的加深,治疗理念也有所转变,更提倡在规范抗癫痫发作治疗的基础上,早期及时免疫治疗和综合支持。本文从FIRES的定义、临床特征、辅助检查、发病机制、诊断及评估、治疗、预后和未来研究方向进行了全面阐述,以期提高认识,改善预后。Febrile infection-related epilepsy syndrome is an inflammation-related acute encephalopathy that occurs in previously healthy children and adolescents.It is clinically characterized by super-refractory status epilepticus that occurs after a febrile infection and is often associated with poor prognosis.In recent years,with a deeper understanding of this disease,the treatment approaches have shifted to early and timely immunotherapy and comprehensive support on the basis of standardized anti-epileptic seizure treatment.This review comprehensively elaborates the definition,clinical characteristics,auxiliary examinations,pathogenesis,diagnosis and evaluation,treatment,prognosis,and future research directions of febrile infection-related epilepsy syndrome,aiming to enhance understanding and improve prognosis.

关 键 词：热性感染相关性癫痫综合征 新发生的难治性癫痫持续状态 感染诱发性脑病综合征 

分 类 号：R729[医药卫生—儿科]