新诊断T2DM患者PNI与DPN的相关性研究  

Correlation study of PNI and DPN in patients with newly diagnosed T2DM

作　　者：蔡佳瑶 彭宇辉 陈雪 郑海飞 林怡 CAI Jiayao;PENG Yuhui;CHEN Xue;ZHENG Haifei;LIN Yi(Department of Endocrinology,Wenzhou People’s Hospital,the Third Affiliated Hospital of Shanghai University,Wenzhou 325000,Zhejiang,China)

机构地区：[1]温州市人民医院上海大学附属第三医院内分泌科,浙江温州325000

出　　处：《中国现代医生》2025年第8期24-27,共4页China Modern Doctor

基　　金：浙江省温州市科学技术局基础性公益科研项目(Y2023370)。

摘　　要：目的探讨预后营养指数(prognostic nutritional index,PNI)在新诊断2型糖尿病(type 2 diabetes mellites,T2DM)患者糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)中的临床意义。方法选取2017年1月至2023年3月在温州市人民医院住院的新诊断T2DM患者300例,根据是否合并DPN分为非DPN组(n=214)与DPN组(n=86),比较两组患者的一般资料、生化指标、PNI等临床指标。Logistic回归分析不同组DPN的发生风险,采用受试者操作特征曲线分析各指标的预测价值。结果与非DPN组比较,DPN组患者的PNI更低(P<0.05);较低水平PNI与较高DPN发病风险相关(P<0.001);PNI对DPN诊断的曲线下面积为0.882(95%CI:0.841~0.923,P<0.001),且PNI对DPN的预测价值优于系统免疫炎症指数、中性粒细胞/淋巴细胞比值。结论新诊断T2DM患者PNI与DPN的发生密切相关,PNI或可作为筛查T2DM患者并发DPN的一项重要指标。Objective To evaluate the prognostic nutritional index(PNI)in patients with newly diagnosed type 2 diabetes mellites(T2DM)complicated with diabetic peripheral neuropathy(DPN).Methods A total of 300 patients with newly diagnosed T2DM from the Wenzhou People’s Hospital during January 2017 to March 2023 were enrolled in this study.The patients were divided into uncomplicated DPN(n=214)and complicated DPN(n=86).The general data,biochemical indicators,PNI and other clinical indicators of the two groups were compared.According to PNI thirds,patients were divided into three groups:low,medium and high,comparing the proportion of DPN among the three groups;Logistic regression calculated the risk of DPN in different groups;Drawing receiver operating characteristic curve to analyze PNI and other indicators to predict the value of DPN.Results Compared with the non-DPN group,patients had lower PNI in the DPN group(P<0.05);lower PNI was associated with higher risk of DPN(P<0.001).Area under the curve of PNI was 0.882(95%CI:0.841-0.923,P<0.001),and better predictive value of PNI for DPN than the systemic immune inflammation index,the neutrophil/lymphocyte ratio.Conclusion PNI is closely associated with the occurrence of DPN in newly diagnosed T2DM complicated,and PNI may be used as an important indicator for screening patients with T2DM complicated with DPN.

关 键 词：2型糖尿病 糖尿病周围神经病变 预后营养指数 

分 类 号：R589.2[医药卫生—内分泌]