不同方案治疗维持性血液透析患者皮肤瘙痒的疗效对比  

Comparison of efficacy of different regimens treating pruritus in patients undergoing maintenance hemodialysis

作　　者：邵苏珍 章毅 徐慧娟 黄建 丁凡 SHAO Suzhen;ZHANG Yi;XU Huijuan;HUANG Jian;DING Fan(Department of Nephrology,the Sixth People’s Hospital of Jiujiang City,Jiujiang 332000,Jiangxi,China)

机构地区：[1]九江市第六人民医院肾内科,江西九江332000

出　　处：《中国现代医生》2025年第8期62-65,共4页China Modern Doctor

基　　金：江西省卫生健康委科技计划项目(202311653)。

摘　　要：目的对比不同方案治疗维持性血液透析(maintenance hemodialysis,MHD)患者皮肤瘙痒的临床疗效。方法选取2022年8月1日至2024年4月30日九江市第六人民医院收治MHD患者共50例,采用随机数字表法分为两组。对照组(n=25)采用硫代硫酸钠治疗,观察组(n=25)在对照组基础上联合加巴喷丁治疗。治疗8周后比较两组的治疗效果。结果观察组患者的临床总有效率明显高于对照组(P<0.05);治疗8周后,两组患者的生活质量各维度评分和总分均高于治疗前,且观察组患者高于对照组(P<0.05)。结论应用硫代硫酸钠联合加巴喷丁治疗MHD患者皮肤瘙痒,不仅能缓解患者的瘙痒症状,改善患者睡眠质量,提高生活质量,且安全性良好。Objective To compare clinical efficacy of different regimens in treatment of pruritus in maintenance hemodialysis(MHD)patients.Methods A total of 50 patients with MHD admitted to the Sixth People’s Hospital of Jiujiang City from August 1,2022 to April 30,2024 as subjects and were divided into two groups according to random number table method.Control group(n=25)was treated with sodium thiosulfate.On this basis,gabapentin combination therapy was added in observation group(n=25).Effects of two groups were compared after 8 weeks of treatment.Results Total clinical effective rate of observation group was significantly higher than that of control group(P<0.05).After 8 weeks of treatment,scores and total scores of all dimensions of quality of life in two groups were higher than before treatment,and observation group was higher than control group(P<0.05).Conclusion Sodium thiosulfate combined with gabapentin in treatment of MHD patients with pruritus can not only relieve pruritus symptoms,improve sleep quality,but also have good safety.

关 键 词：硫代硫酸钠 维持性血液透析 皮肤瘙痒 尿毒症 

分 类 号：R459.5[医药卫生—治疗学]