镁基生物材料在骨科中的改性研究进展  

Advances in research on the modification of magnesium-based biomaterials for orthopedic application

作　　者：朱振东[1] 皇甫晶晶 李月 路坦 姜来[4] 胡涛 任文杰 ZHU Zhendong;HUANGFU Jingjing;LI Yue;LU Tan;JIANG Lai;HU Tao;REN Wenjie(Clinical Medical Center of Tissue Engineering and Regeneration,Xinxiang Medical University,Xinxiang 453003,Henan Province,China;Henan Medical Key Laboratory for Research of Trauma and Orthopedics,the Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,Henan Province,China;Department of Orthopedics,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453003,Henan Province,China;Nanjing Wuyuedao Medical Technology Development Co.,Ltd.,Nanjing 210000,Jiangsu Province,China;Shanghai Xiaobo Technology Development Co.,Ltd.,Shanghai 200120,China)

机构地区：[1]新乡医学院组织工程与再生临床医学中心,河南新乡453003 [2]新乡医学院第三附属医院河南省创伤与骨科研究医学重点实验室,河南新乡453003 [3]新乡医学院第一附属医院骨科,河南卫辉453100 [4]南京吾岳道医疗科技发展有限公司,江苏南京210000 [5]上海骁博科技发展有限公司,上海200120

出　　处：《新乡医学院学报》2025年第4期260-265,共6页Journal of Xinxiang Medical University

基　　金：国家自然科学基金面上项目(编号:80471191);国家重点研发计划项目(编号:2024YFA1107804)。

摘　　要：随着生物医学工程的不断发展,镁基生物材料因其优异的生物相容性、适中的密度以及良好的生物降解性,成为骨科植入材料研究的热点。镁基生物材料能够在体内逐渐降解并被骨组织吸收,从而避免传统金属生物材料在治疗过程中需要二次手术取出的弊端。然而,镁基生物材料仍然面临降解速率过快、耐腐蚀性较差、力学性能不稳定等问题,限制了其在临床上的广泛应用。为了解决这些挑战,研究人员开发了多种改性方法,包括合金化、表面处理、多孔结构设计以及纳米技术等。本文总结了镁基生物材料的基本特性,探讨了各类改性技术的原理、优势与局限性,并展望了未来的发展方向。With the continuous advancement of biomedical engineering,magnesium-based biomaterials have become a research hotspot in orthopedic applications due to their excellent biocompatibility,moderate density,and favorable biodegrada-bility.Unlike traditional metallic biomaterials,these materials can gradually degrade in vivo and be absorbed by bone tissue,requiring no secondary surgical removal.However,magnesium-based biomaterials still face challenges such as rapid degradation,poor corrosion resistance,and mechanical instability,which hinder their widespread clinical application.To address these limitations,researchers have developed various modification strategies,including alloying,surface treatment,porous structure design,and nanotechnology.In this review,the fundamental properties of magnesium-based biomaterials are summarized,the principles,advantages,and limitations of various modification techniques are explored,and future research directions are discussed.

关 键 词：镁基生物材料 骨科植入材料 合金化改性 表面处理 多孔化 纳米技术 

分 类 号：R683[医药卫生—骨科学] R318[医药卫生—外科学]