老年慢性心力衰竭患者血清可溶性转铁蛋白受体及可溶性纤维蛋白原2水平与心功能指标及心室重构的相关性  

Correlation of serum soluble transferrin receptor and soluble fibrinogen-like protein 2 levels with cardiac function indicators and ventricular remodeling in elderly patients with chronic heart failure

作　　者：沈惠峰 张小飞 卢黎敏 Shen Huifeng;Zhang Xiaofei;Lu Limin(Department of Cardiology,Second People's Hospital of Zhangjiagang City,Zhangjiagang 215600,China;Department of Cardiology,Nanjing First People's Hospital,Nanjing 210006,China)

机构地区：[1]江苏省张家港市第二人民医院心内科,215600 [2]江苏省南京市第一人民医院心内科,210006

出　　处：《心脑血管病防治》2025年第2期36-39,47,共5页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

摘　　要：目的探讨老年慢性心力衰竭(CHF)患者血清可溶性转铁蛋白受体(sTfR)、可溶性纤维蛋白原2(sFGL2)水平与心功能指标、心室重构的相关性。方法选取2022年6月至2023年9月江苏省张家港市第二人民医院收治的122例老年CHF患者作为CHF组,参照美国纽约心脏协会(NYHA)心功能分级标准,将老年CHF患者分为Ⅱ级40例、Ⅲ级45例和Ⅳ级37例,同时选取健康体检者109例作对照组,采用酶联免疫吸附法检测血清sTfR、sFGL2水平,超声心动图检测仪检测心功能及心室重构指标:心输出量(CO)、左心室射血分数(LVEF)、左心室后壁厚度(LVPWT)、左心室舒张末期内径(LVEDD)、左心房内径(LAD)、左心室质量指数(LVMI)、左心室重构指数(LVRI),Pearson法分析血清sTfR,sFGL2水平与心功能指标、心肌重构的相关性。结果与对照组比较,CHF组血清sTfR升高(t=12.667,P<0.01),sFGL2水平降低(t=10.608,P<0.01)。CHF组LVPWT、LVEDD、LAD、LVMI高于对照组(t=6.684、12.047、9.474、6.687,P<0.01),CO、LVEF、LVRI低于对照组(t=5.091、8.552、8.562,P<0.01)。随着心功能分级升高,sTfR、LVPWT、LVEDD、LAD、LVMI水平升高(F=38.538、60.125、65.663、42.303、34.412,P<0.01),sFGL2、CO、LVEF、LVRI水平降低(F=48.900、69.286、29.240、26.350,P<0.01)。老年CHF患者血清sTfR水平与LVPWT、LVEDD、LAD、LVMI呈正相关(r=0.609、0.586、0.562、0.545,P<0.01),与CO、LVEF、LVRI呈负相关(r=-0.651、-0.696、-0.710,P<0.01);sFGL2水平与LVPWT、LVEDD、LAD、LVMI呈负相关(r=-0.636、-0.581、-0.594、-0.511,P<0.01),与CO、LVEF、LVRI呈正相关(r=0.652、0.649、0.746,P<0.01)。结论老年CHF患者血清sTfR水平升高,sFGL2水平降低,与老年CHF患者心功能指标、心室重构相关,可作为评价老年CHF患者心功能指标、心室重构的血清标志物。Objective To investigate the correlation of serum soluble transferrin receptor(sTfR)and soluble fibrinogen-like protein 2(sFGL2)levels with cardiac function indicators and ventricular remodeling in elderly patients with chronic heart failure(CHF).Methods From June 2022 to September 2023,122 elderly CHF patients treated at the Second People's Hospital of Zhangjiagang City were collected as the CHF group.According to the New York Heart Association(NYHA)cardiac function grading standards,the CHF group was divided into ClassⅡ(40 cases),ClassⅢ(45 cases),and ClassⅣ(37cases).Additionally,109 healthy individuals undergoing routine physical examinations were included as the control group.Serum sTfR and sFGL2 levels were measured using enzymelinked immunosorbent assay.Cardiac function and ventricular remodeling indicators were assessed using echocardiography,including cardiac output(CO),left ventricular ejection fraction(LVEF),left ventricular posterior wall thickness(LVPWT),left ventricular end-diastolic diameter(LVEDD),left atrial diameter(LAD),left ventricular mass index(LVMI),and left ventricular remodeling index(LVRI).Pearson correlation analysis was used to evaluate the association between serum sTfR,sFGL2 levels and cardiac function and ventricular remodeling parameters.Results Compared to the control group,serum sTfR in the CHF group was significantly increased(t=12.667,P<0.01),while the sFGL2 level was significantly reduced(t=10.608,P<0.01).The LVPWT,LVEDD,LAD,and LVMI in the CHF group were significantly higher than those in the control group(t=6.684,12.047,9.474,6.687;P<0.01),while CO,LVEF,and LVRI were significantly lower(t=5.091,8.552,8.562;P<0.01).With the increase in heart function classification,sTfR,LVPWT,LVEDD,LAD,and LVMI levels increased(F=38.538,60.125,65.663,42.303,34.412;P<0.01),while sFGL2,CO,LVEF,and LVRI levels decreased(F=48.900,69.286,29.240,26.350;P<0.01).In elderly CHF patients,serum sTfR levels were positively correlated with LVPWT,LVEDD,LAD,and LVMI(r=0.609,0.586,0.562,0.545;P<0.01),but

关 键 词：老年慢性心力衰竭 可溶性转铁蛋白受体 可溶性纤维蛋白原2 心功能 心室重构 

分 类 号：R54[医药卫生—心血管疾病]