线粒体稳态在类风湿关节炎致病中的作用  

Role of mitochondrial homeostasis in the pathogenesis of rheumatoid arthritis

作　　者：贾东晔 潘志[1] JIA Dongye;PAN Zhi(Jilin Ginseng Academy,Changchun University of Chinese Medicine,Changchun 130117,Jilin,China)

机构地区：[1]长春中医药大学人参科学研究院,吉林长春130117

出　　处：《中国临床药理学与治疗学》2025年第4期541-547,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金项目(82074324);吉林省科技厅项目(YDZJ202201ZYTS185);吉林省科技厅项目(20230508065RC)。

摘　　要：类风湿关节炎(rheumatoid arthritis,RA)是慢性炎症过程相关的自身免疫性疾病,可损害关节和关节外器官,包括心脏、肾脏、肺、消化系统、眼睛、皮肤和神经系统。在RA期间,线粒体稳态发生改变并通过影响软骨和滑膜组织,导致炎症因子的产生和关节损伤,从而加速RA的发展。调控线粒体稳态是延缓RA发病的关键环节之一。本文以“类风湿关节炎”和“线粒体稳态”作为主题词进行检索近十年的相关文献,归纳分析RA导致线粒体稳态失衡的原因及调控线粒体稳态在改善RA中的作用,以期为RA的治疗提供新的思路和方法。Rheumatoid arthritis(RA)is a chronic inflammatory autoimmune disease that can affect joints and extra-articular organs,including the heart,kidneys,lungs,digestive system,eyes,skin,and nervous system.During RA,mitochondrial homeostasis is altered,leading to the production of inflammatory mediators and joint damage by affecting cartilage and synovial tissues.Regulating mitochondrial homeostasis is a key step in slowing the progression of RA.This study conducts a comprehensive literature review on the topics of"rheumatoid arthritis"and"mitochondrial homeostasis"over the past decade.It aims to summarize and analyze the factors contributing to mitochondrial homeostasis imbalance in RA,as well as the potential role of modulating mitochondrial homeostasis in ameliorating RA,with the ultimate goal of offering novel insights and approaches for RA treatment.

关 键 词：类风湿关节炎 线粒体稳态 线粒体动力学 能量代谢 

分 类 号：R593.22[医药卫生—内科学]