巨噬细胞极化与心血管疾病研究进展  

Research progress on the role of macrophage polarization in cardiovascular diseases

作　　者：崔涵雨 胡长平 CUI Hanyu;HU Changping(Department of Pharmacology,Xiangya School of Pharmaceutical Sciences,Central South University,Hunan Provincial Key Laboratory of Cardiovascular Research,Changsha 410078,Hunan,China)

机构地区：[1]中南大学湘雅药学院药理学系,心血管研究湖南省重点实验室,湖南长沙410078

出　　处：《中国临床药理学与治疗学》2025年第4期548-555,共8页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金资助项目(82241025)。

摘　　要：巨噬细胞作为吞噬性先天免疫细胞,与多种组织类型相互作用,在免疫防御、炎症反应和组织重构中发挥重要作用。当组织微环境发生变化时,巨噬细胞通过极化为经典激活的M1型和替代活化的M2型,或更复杂表型,参与疾病的发生发展。本文重点聚焦于巨噬细胞极化在心血管疾病中的应用,通过巨噬细胞起源和活化等方面深入了解巨噬细胞,阐述巨噬细胞极化与心血管疾病的关系,并提出靶向巨噬细胞治疗的策略,为改善心血管疾病的炎症状态提供理论基础。As phagocytic innate immune cells,macrophages interact with various tissue types and play an important role in immune defense,inflammatory response and tissue remodeling.Macrophages participate in the occurrence and development of disease by polarizing into classically activated M1 type and substitutively activated M2 type,or more complex phenotypes,when the tissue microenvironment changes.This paper focused on the application of macrophage polarization in cardiovascular diseases,and introduces macrophage origin and activation to propose the relationship between macrophage polarization and cardiovascular diseases.Then,the strategies for targeted macrophage therapy were proposed to provide an important theoretical basis for improving the inflammatory state of cardiovascular diseases.

关 键 词：巨噬细胞极化 炎症 心血管疾病 转录调控 

分 类 号：R54[医药卫生—心血管疾病]