新生儿红细胞输注疗效影响因素的回顾性分析  

Influencing factors of neonatal red blood cell transfusion:a retrospective analysis

作　　者：周娜 何鑫 司宇 侯忱 陈家璐 汤朝晖[1] ZHOU Na;HE Xin;SI Yu;HOU Chen;CHEN Jialu;TANG Zhaohui(Department of Blood Transfusion,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)

机构地区：[1]上海交通大学医学院附属新华医院输血科,上海200092

出　　处：《中国输血杂志》2025年第3期375-381,共7页Chinese Journal of Blood Transfusion

基　　金：上海交通大学医学院附属新华医院“千天计划”课题(15QT15)。

摘　　要：目的 分析不同因素、不同红细胞输注阈值对新生儿红细胞输注疗效的影响,为新生儿输血提供更多的参考,从而更好地实现合理、有效用血。方法 回顾性收集2022-2023年共282例在本院接受红细胞输注的新生儿资料,包括新生儿出生时体重、胎龄、输血次数、住院天数、输红细胞时辅助通气情况以及输血前后实验室检查结果等相关信息,使用SPSS软件进行统计学分析,综合分析不同因素对新生儿红细胞输注疗效的影响。结果 新生儿出生时的胎龄和体重与其住院时长、红细胞输注次数呈负相关,胎龄越小、体重越低的新生儿其住院时间越长,住院期间输红细胞的次数越多。按照15 mL/kg这一标准输注红细胞后,在不同的红细胞输注阈值下红细胞输注疗效存在统计学差异。其中非危重病情下,输血前Hb值>120 g/L时,红细胞输注无效;输血前Hb值≤70 g/L时在危重及非危重2种情况下均能取得较好的输血疗效。结论 危重情况下,输血前Hb值≤70 g/L组的红细胞输注效果最好;非危重情况下输血前Hb值81~90 g/L组的红细胞输注效果最好。整体来看,非危重情况下的红细胞输注疗效高于危重情况下的红细胞输注疗效。Objective To analyze the effects of different factors and red blood cell transfusion thresholds on the efficacy of neonatal red blood cell(RBC)transfusion,in order to provide more references for neonatal transfusions to better achieve rational and effective blood use.Methods A retrospective collection of data from 282 neonates who received RBC transfu-sions at our hospital from 2022 to 2023 was conducted,including birth weight,gestational age,number of blood transfu-sions,length of hospital stay,assisted ventilation during RBC transfusion,and laboratory test results before and after trans-fusion.SPSS software was used for statistical analysis to comprehensively analyze the impact of different factors on the effica-cy of RBC transfusion in neonates.Results The results showed that the gestational age and weight of newborns at birth were negatively correlated with their length of hospital stay and the number of RBC transfusions during hospitalization.New-borns with younger gestational age and lower weight had longer hospital stays and more RBC transfusions during hospitaliza-tion.After administering RBCs according to the standard of 15 mL/kg,there was a statistically significant difference in the efficacy of RBC transfusion at different transfusion thresholds.In non-critical situations,RBC transfusions were ineffective when the pre-transfusion hemoglobin(Hb)level was>120 g/L.When the pre-transfusion Hb level was≤70 g/L,RBC transfusions achieved higher efficacy in both critical and non-critical situations.Conclusion In critical situations,the group with pre-transfusion Hb values≤70 g/L has the best RBC transfusion effect,while in non-critical situations,the group with pre-transfusion Hb levels between 81 and 90 g/L has the best RBC transfusion effect.Overall,the efficacy of RBC transfusion in non-critical situations is higher than that in critical situations.

关 键 词：新生儿 早产儿 红细胞输注 输注阈值 输注疗效 

分 类 号：R515.3[医药卫生—内科学]