血小板在肿瘤发展中的动态作用及以其为基础的治疗手段  

The role of platelets in tumor development and the treatments based on them

作　　者：路奇 杜莉莉 孙进[1] LU Qi;DU Lili;SUN Jin(Shenyang Pharmaceutical University,Wuya College of Innovation,Shenyang 110016,Liaoning,China)

机构地区：[1]沈阳药科大学无涯创新学院,辽宁沈阳110016

出　　处：《中国临床药理学与治疗学》2025年第3期290-296,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家重点研发计划项目(2022YFE0111600)。

摘　　要：除凝血功能外,血小板在肿瘤发生、发展及转移等过程中起关键性作用。肿瘤与血小板相互作用可以产生“肿瘤诱导血小板”,并导致血小板多种特征的变化。此外,活化的血小板还会抑制化疗或免疫治疗的效果,因此抑制血小板激活或耗竭血小板能有效提高肿瘤预后。本文详细介绍了血小板在肿瘤发展过程中的关键性作用,对其在肿瘤诊断及监测治疗中的应用进行了总结,并重点讨论了如何以血小板为基础开发精准的递送策略以实现高效安全的肿瘤治疗。The platelets play the important role in tumor angiogenesis,growth,and metastasis,in addition to coagulation.The interaction between tumors and platelets can produce"tumor-induced platelets",which leads various changes of platelet characteristics.In addition,activated platelets can also inhibit the effects of both chemotherapy and immunotherapy,therefore,both inhibiting platelet activation and depleting platelets can effectively improve tumor prognosis.In this review,we introduced the key role of platelets in the development of tumors,summarized their application in tumor diagnosis,monitoring,and treatment,and provided our view on how to develop precise delivery strategies based on platelets for achieve efficient and safe tumor treatment.

关 键 词：血小板 肿瘤治疗 临床检测指标 靶向递送 

分 类 号：R331.143[医药卫生—人体生理学] R730[医药卫生—基础医学]