皱皮木瓜治疗类风湿性关节炎骨破坏作用机制研究进展  

Research progress on mechanism of action of Chaenomeles speciosa Nakai in the treatment of rheumatoid arthritis bone restruction

作　　者：曹郡 周俨淋 艾正文 李世刚[1] CAO Jun;ZHOU Yanlin;AI Zhengwen;LI Shigang(College of Basic Medical Science,China Three Gorges University,Yichang 443002,Hubei,China;College of Medicine and Health Sciences China Three Gorges University,Yichang 443002,Hubei,China;Third-grade Pharmacological Laboratory on Traditional Chinese Medicine,State Administration of Traditional Chinese Medicine,China Three Gorges University,Yichang 443002,Hubei,China)

机构地区：[1]三峡大学基础医学院,湖北宜昌443002 [2]三峡大学健康医学院,湖北宜昌443002 [3]三峡大学国家中医药管理局中药药理科研三级实验室,湖北宜昌443002

出　　处：《中国临床药理学与治疗学》2025年第3期404-411,共8页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金资助项目(82274170);国家自然科学基金资助项目(81673665)。

摘　　要：类风湿性关节炎(RA)是一种以进行性骨破坏为特征的自身免疫性疾病,早期因滑膜炎症引起关节肿胀,中晚期随着炎症发展,软骨和骨发生破坏而导致关节畸形,三年内致残致畸率达75%,防治RA骨关节破坏具有紧迫性,因此寻找治疗RA骨破坏的有效药物具有重大意义。研究表明皱皮木瓜可以治疗RA骨破坏,但成分和作用机制不明,因此本综述旨在对皱皮木瓜中有效活性成分治疗类风湿性关节炎骨破坏的作用机制进行概述,为中药抗RA骨破坏新型制剂开发提供依据和方向。Rheumatoid arthritis is an autoimmune disease characterized by progressive bone destruction,with joint swelling caused by synovial inflammation in the early stage,and joint deformity caused by cartilage and bone destruction occurring in the middle and late stages as inflammation develops,resulting in a 75%disability and deformity rate within three years,and the prevention and treatment of RA bone and joint destruction is of urgency,and it is therefore of great significance to search for effective drugs to treat RA bone destruction.Studies have shown that wrinkled skin papaya can treat RA bone destruction,but the composition and mechanism of action are unknown,so this review aims to provide an overview of the mechanism of action of the effective active ingredients in wrinkled skin papaya for the treatment of rheumatoid arthritis bone destruction,and to provide a basis and direction for the development of novel formulations of traditional Chinese medicines for anti-RA bone destruction.

关 键 词：皱皮木瓜 破骨细胞 骨破坏 类风湿性关节炎 作用机制 

分 类 号：R593.22[医药卫生—内科学]