质子治疗剂量测量的光纤剂量计研究现状与进展  

Current research status and progress of fiber-optic dosimeters for proton therapy dosimetry

作　　者：王明[1,2] 孙甜甜 廖晟 谢国昱 董浪 代伟 张庆贤 WANG Ming;SUN Tiantian;LIAO Sheng;XIE Guoyu;DONG Lang;DAI Wei;ZHANG Qingxian(College of Nuclear Technology and Automation Engineering,Chengdu University of Technology,Chengdu 610059,China;Applied Nuclear Technology in Geosciences Key Laboratory of Sichuan Province(Chengdu University of Technology),Chengdu 610059,China)

机构地区：[1]成都理工大学核技术与自动化工程学院,成都610059 [2]地学核技术四川省重点实验室(成都理工大学),成都610059

出　　处：《核技术》2025年第3期1-16,共16页Nuclear Techniques

基　　金：国家自然科学基金(No.12105030);四川省自然科学基金面上项目(No.2025ZNSFSC0083);计量与校准技术重点实验室基金(No.JLKG2023001C002)资助

摘　　要：质子治疗作为一种先进的放射治疗技术,因其精准的剂量分布和对周围正常组织的最小化损伤而受到重视。质子束的精确剂量测量是确保治疗效果和安全性的关键。光纤剂量计因其独特的优势(如高空间分辨率、实时监测能力、水等效性和抗电磁干扰能力)成为质子治疗剂量学研究的热点。本文综述了光纤剂量计在质子治疗剂量测定中的技术原理、应用现状、发展挑战和未来趋势。首先,本文概述了光纤剂量计的发光机制,并对它们的工作原理进行了介绍;其次,本文讨论了基于不同发光机制的光纤剂量计在临床质子治疗中的实用性、对高剂量率适应性和准确性,同时,也指出了当前光纤剂量计技术在质子治疗中面临的挑战及解决方案,如应用闪烁猝灭校正来减少猝灭效应;最后,本文展望了光纤剂量计技术的发展前景,特别是在超高剂量率治疗(如Flash治疗)中的应用潜力,以及如何通过材料科学和光电技术的创新来克服现有限制。通过本综述,旨在为研究人员和临床医生提供一个全面的视角,以提高质子治疗的精确性和治疗效果。As an advanced radiation therapy technique,proton therapy is valued for its precise dose distribution and minimized damage to surrounding normal tissues.Accurate dosimetry of proton beams is crucial to ensure treatment efficacy and safety of proton therapy.Fiber optic dosimeters have become a hotspot for proton therapy dosimetry research due to their unique advantages,such as high spatial resolution,real-time monitoring capability,waterequivalence,and resistance to electromagnetic interference.In this paper,the technical principles,current application status,development challenges and future trends of fiber optic dosimeters in proton therapy dosimetry are reviewed to provide researchers and clinicians with a comprehensive perspective to improve the accuracy and therapeutic efficacy of proton therapy.Firstly,the luminescence mechanisms of fiber optic dosimeters are outlined and their working principles are briefly described.Then,based on different luminescence mechanisms in clinical proton therapy,the utility of fiber optic dosimeters is discussed for high dose rate adaptability and accuracy.Meanwhile,the challenges and solutions are addressed to the current fiber optic dosimeter technology,such as applying burst quenching correction reduce the burst effect.Finally,the future development of fiber optic dosimeter technology is prospected,especially for its potential application in ultra-high dose rate treatments such as Flash therapy,and how existing limitations can be overcome through innovations in materials science and optoelectronic technology.

关 键 词：质子治疗 光纤剂量计 剂量测定 FLASH治疗 

分 类 号：TL99[核科学技术—核技术及应用]