盐酸氨溴索治疗慢阻肺合并肺部感染的临床疗效观察  

Observation on clinical efficacy of ambroxol hydrochloride in the treatment of chronic obstructive pulmonary disease complicated with pulmonary infection

作　　者：任长寿 王宏生 REN Chang-shou;WANG Hong-sheng(Respiratory Department,The 943rd Hospital of the Joint Service Support Force of the Chinese People's Liberation Army,Wuwei 733000,China)

机构地区：[1]中国人民解放军联勤保障部队第九四三医院呼吸科,733000

出　　处：《中国实用医药》2025年第5期6-10,共5页China Practical Medicine

摘　　要：目的分析盐酸氨溴索治疗慢性阻塞性肺疾病(慢阻肺)合并肺部感染的疗效。方法选取慢阻肺合并肺部感染患者100例,随机分成对照组、观察组,各50例。对照组实施常规治疗,观察组在对照组基础上增加盐酸氨溴索治疗。对比两组治疗效果、症状消失时间、住院时间、肺功能指标[第1秒用力呼气容积(FEV1)、呼气峰值流速(PEF)、第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)、每分钟最大通气量(MMV)]、生活质量及不良反应发生情况。结果观察组治疗总有效率98.00%高于对照组的80.00%(P<0.05)。观察组肺部湿啰音、咳嗽咳痰、胸闷气短消失时间及住院时间分别为(5.26±0.64)、(5.12±0.87)、(3.10±0.21)、(7.68±0.29)d,均短于对照组的(7.85±1.50)、(8.56±1.20)、(5.26±0.84)、(10.58±1.81)d(P<0.05)。治疗后,观察组FEV1(2.92±0.12)L、PEF(198.36±8.52)L/min、FEV1/FVC(79.49±3.26)%、MMV(102.12±2.59)L均大于对照组的(2.41±0.52)L、(178.48±13.15)L/min、(74.74±9.52)%、(90.26±8.26)L(P<0.05)。治疗后,观察组活力状况、生理职能、情感职能、社会功能评分分别为(72.41±2.26)、(75.84±2.42)、(72.49±2.25)、(73.68±2.24)分,均高于对照组的(60.63±7.15)、(61.36±8.59)、(62.64±6.25)、(63.46±7.28)分(P<0.05)。两组不良反应发生率对比差异不显著(P>0.05)。结论于慢阻肺合并肺部感染患者给予盐酸氨溴索治疗的效果显著,可缩短康复时间,改善肺功能,提升患者生活质量,安全有效。Objective To analyze the efficacy of ambroxol hydrochloride in the treatment of chronic obstructive pulmonary disease complicated with pulmonary infection.Methods A total of 100 patients with COPD complicated with pulmonary infection were randomly divided into a control group and an observation group,with 50 cases in each group.The control group received conventional treatment,and the observation group was treated with ambroxol hydrochloride on the basis of the control group.Comparison of treatment effect,symptom resolution time,length of hospital stay,pulmonary function index[forced expiratory volume in one second(FEV1),peak expiratory flow rate(PEF),FEV1/FVC,maximum minute ventilation(MMV)],quality of life and occurrence of adverse reactions between the two groups.Results The total effective rate of 98.00%in the observation group was higher than 80.00%in the control group(P<0.05).In the observation group,the resolution time of lung moist rale,cough and sputum,chest tightness and shortness of breath and length of hospital stay were(5.26±0.64),(5.12±0.87),(3.10±0.21)and(7.68±0.29)d,which were shorter than(7.85±1.50),(8.56±1.20),(5.26±0.84)and(10.58±1.81)d in the control group(P<0.05).After treatment,the observation group had FEV1 of(2.92±0.12)L,PEF of(198.36±8.52)L/min,FEV1/FVC of(79.49±3.26)%,and MMV of(102.12±2.59)L/m,which were higher than(2.41±0.52)L and(178.48±13.15)L/min,(74.74±9.52)%,and(90.26±8.26)L in the control group(P<0.05).After treatment,the scores of vitality,role-physical,role-emotional and social function in the observation group were(72.41±2.26),(75.84±2.42),(72.49±2.25)and(73.68±2.24)points,which were higher than(60.63±7.15),(61.36±8.59),(62.64±6.25)and(63.46±7.28)points in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion For patients with COPD complicated with pulmonary infection,ambroxol hydrochloride has a significant effect,which can shorten the recovery time,improve pulmonar

关 键 词：盐酸氨溴索 慢性阻塞性肺疾病 肺部感染 肺功能 临床症状 

分 类 号：R56[医药卫生—呼吸系统]