普米克辅助孟鲁司特对小儿哮喘的效果研究  

Study on the effect of Pulmicort combined with montelukast on pediatric asthma

作　　者：李远 LI Yuan(First Department of Pediatrics,Shouguang People's Hospital,Shouguang 262700,China)

机构地区：[1]寿光人民医院小儿一科,262700

出　　处：《中国实用医药》2025年第5期91-94,共4页China Practical Medicine

摘　　要：目的分析布地奈德气雾剂(商品名:普米克)辅助孟鲁司特对小儿哮喘的疗效。方法选取100例小儿哮喘患儿,使用奇偶数形式分为常规组和观察组,各50例。常规组单用普米克治疗,观察组采用普米克辅助孟鲁司特治疗。比较两组患儿哮喘症状评分、肺功能、用药不良反应发生率。结果两组治疗前胸闷、咳嗽、喘息、气短、咳痰评分比较无差异(P>0.05);治疗后,观察组胸闷、咳嗽、喘息、气短、咳痰评分分别为(1.05±0.26)、(1.13±0.35)、(1.57±0.12)、(0.76±0.22)、(0.96±0.12)分,均低于常规组的(2.24±0.31)、(2.15±0.29)、(2.34±0.18)、(2.12±0.37)、(2.09±0.16)分(P<0.05)。两组治疗前第1秒用力呼气容积、用力肺活量、呼气峰值流速比较无差异(P>0.05);治疗后,观察组第1秒用力呼气容积(1.57±0.19)L、用力肺活量(1.89±0.17)L、呼气峰值流速(143.68±15.31)L/min显著高于常规组的(1.23±0.23)L、(1.72±0.25)L、(131.21±19.45)L/min(P<0.05)。观察组、常规组用药不良反应发生率比较无差异(P>0.05)。结论普米克辅助孟鲁司特治疗小儿哮喘,能够使患儿哮喘症状评分显著下降,利于其肺功能恢复。Objective To analyze the curative effect of budesonide(trade name:Pulmicort)combined with montelukast on pediatric asthma.Methods A total of 100 children with asthma were selected and divided into conventional group and observation group,with 50 cases in each group.The conventional group was treated with Pulmicort alone,and the observation group was treated with Pulmicort combined with montelukast.The asthma symptom score,lung function and incidence of adverse drug reactions were compared between the two groups.Results Before treatment,there were no differences in scores of chest tightness,cough,wheezing,shortness of breath and expectoration between the two groups(P>0.05).After treatment,the scores of chest tightness,cough,wheezing,shortness of breath and expectoration were(1.05±0.26),(1.13±0.35),(1.57±0.12),(0.76±0.22)and(0.96±0.12)points in the observation group,which were lower than(2.24±0.31),(2.15±0.29),(2.34±0.18),(2.12±0.37)and(2.09±0.16)points in the conventional group(P<0.05).Before treatment,there were no differences in forced expiratory volume in one second,forced vital capacity and peak expiratory flow rate between the two groups(P>0.05).After treatment,the forced expiratory volume in one second,forced vital capacity and peak expiratory flow rate of the observation group were(1.57±0.19)L,(1.89±0.17)L and(143.68±15.31)L/min,which were significantly higher than(1.23±0.23)L,(1.72±0.25)L and(131.21±19.45)L/min of the conventional group(P<0.05).There was no difference in the incidence of adverse drug reactions between the observation group and the conventional group(P>0.05).Conclusion Pulmicort combined with montelukast in the treatment of pediatric asthma can significantly reduce the asthma symptom score and facilitate the recovery of lung function of the children.

关 键 词：小儿哮喘 布地奈德气雾剂 孟鲁司特 哮喘症状评分 

分 类 号：R72[医药卫生—儿科]