右美托咪定应用于无痛胃镜中的麻醉效果研究  

Study on the anesthesia effect of dexmedetomidine in painless gastroscopy

作　　者：王莉 WANG Li(Qianhai Life Insurance Guangzhou General Hospital,Guangzhou 511300,China)

机构地区：[1]前海人寿广州总医院,511300

出　　处：《中国实用医药》2025年第5期98-101,共4页China Practical Medicine

摘　　要：目的探讨门诊无痛胃镜检查中应用右美托咪定的临床价值。方法纳入90例接受无痛胃镜检查的患者为研究对象,按1∶1比例分为对照组(45例,采用丙泊酚麻醉)、观察组(45例,在对照组基础上采用盐酸右美托咪定麻醉)。比较两组麻醉情况、镇痛效果、生理指标、不良反应发生率。结果观察组镇痛效果优良率(95.56%)高于对照组(77.78%)(P<0.05)。观察组丙泊酚用量(124.82±20.31)mg少于对照组的(217.53±23.24)mg,苏醒时间(10.02±0.94)min、定向力恢复时间(10.11±1.08)min、麻醉起效时间(4.11±1.25)min短于对照组的(11.25±1.02)、(13.95±1.21)、(6.98±1.54)min,疼痛程度评分(3.11±0.24)分低于对照组的(5.25±0.35)分,镇静评分(3.11±0.34)分优于对照组的(1.35±0.25)分(P<0.05)。两组检查前(T1)、检查后(T3)时血氧饱和度(SpO2)、心率(HR)、收缩压(SBP)、舒张压(DBP)比较无明显差异(P>0.05)。检查中(T2)时观察组SpO2(96.82±1.64)%、SBP(128.98±10.59)mm Hg(1 mm Hg=0.133 kPa)高于对照组的(95.56±1.24)%、(124.22±10.64)mm Hg,HR(79.34±8.42)次/min、DBP(70.25±9.84)mm Hg低于对照组的(90.34±10.64)次/min、(78.41±10.38)mm Hg(P<0.05)。观察组不良反应发生率(13.33%)与对照组(8.89%)比较无明显差异(P>0.05)。结论右美托咪定应用于无痛胃镜检查中麻醉效果确切,可缩短苏醒时间及定向力恢复时间,亦可提高镇痛镇静效果及麻醉安全性,值得借鉴。Objective To explore the clinical value of dexmedetomidine in painless gastroscopy.Methods A study of 90 patients undergoing painless gastroscopy was included,and they were divided into a control group(45 cases,propofol anesthesia)and an observation group(45 cases,dexmedetomidine hydrochloride anesthesia on the basis of the control group).The anesthesia situation,analgesic effect,physiological indicators,and incidence of adverse reactions were compared between the two groups.Results The excellent rate of analgesia in the observation group(95.56%)was higher than that in the control group(77.78%)(P<0.05).The observation group had a less dosage of propofol of(124.82±20.31)mg than(217.53±23.24)mg in the control group;in the observation group,the recovery time was(10.02±0.94)min,the orientation recovery time was(10.11±1.08)min,and anesthesia onset time was(4.11±1.25)min,which were shorter than(11.25±1.02),(13.95±1.21),and(6.98±1.54)min in the control group;the observation group had a lower pain level score of(3.11±0.24)points than(5.25±0.35)points in the control group,and a better sedation score of(3.11±0.34)points than(1.35±0.25)points in the control group(P<0.05).There were no significant differences in blood oxygen saturation(SpO2),heart rate(HR),systolic blood pressure(SBP)and diastolic blood pressure(DBP)between the two groups before examination(T1)and after examination(T3)(P>0.05).During examination(T2),the observation group had SpO2 of(96.82±1.64)%and SBP of(128.98±10.59)mm Hg(1 mm Hg=0.133 kPa),which were higher than(95.56±1.24)%and(124.22±10.64)mm Hg in the control group;the observation group had HR of(79.34±8.42)beats/min and DBP of(70.25±9.84)mm Hg,which were lower than(90.34±10.64)beats/min and(78.41±10.38)mm Hg in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group(13.33%)and the control group(8.89%)(P>0.05).Conclusion Dexmedetomidine has a definite effect in painless gastroscopy,which can shorten the recover

关 键 词：右美托咪定 无痛胃镜 苏醒时间 血压 心率 血氧饱和度 镇静评分 

分 类 号：R61[医药卫生—外科学]