清开灵软胶囊辅助治疗小儿脓毒症毒热证的临床疗效  

Clinical efficacy of Qingkailing soft capsule in adjuvant treatment of sepsis children with heat-toxin syndrome

作　　者：吴家兴 郑贵浪 胡燕[1] 王春[1] 王静[1] 曾汉石 林举择 郭予雄[1] WU Jia-xing;ZHENG Gui-lang;HU Yan(Pediatric Intensive Care Unit,Guangdong Provincial People's Hospital Affiliated to Southern Medical University(Guangdong Academy of Medical Sciences),Guangzhou 519041,China)

机构地区：[1]南方医科大学附属广东省人民医院(广东省医学科学院)儿科重症监护室,519041 [2]南方医科大学附属广东省人民医院(广东省医学科学院)中医科,519041

出　　处：《中国实用医药》2025年第5期129-133,共5页China Practical Medicine

基　　金：广东省中医药局科研项目(项目编号:20221011)。

摘　　要：目的探讨清开灵软胶囊辅助治疗小儿脓毒症毒热证的临床疗效。方法将67例小儿脓毒症毒热证患儿根据不同治疗方法分为对照组(n=39)和观察组(n=28)。对照组使用常规治疗,观察组在对照组基础上使用清开灵软胶囊辅助治疗。对比两组的临床疗效、炎症及凝血标志物、细胞因子、中医证候积分。结果观察组治疗总有效率为96.43%,明显高于对照组的74.36%(P<0.05)。观察组治疗后白细胞计数(WBC)(7.04±1.03)×10^(9)/L、超敏C反应蛋白(hs-CRP)(14.32±3.28)mg/L、降钙素原(PCT)(0.11±0.03)μg/L、中性粒细胞比例(NEUT%)(44.60±5.02)%、D-二聚体(0.67±0.23)mg/L均低于对照组的(9.11±1.12)×10^(9)/L、(16.51±1.79)mg/L、(0.38±0.09)μg/L、(67.31±6.73)%、(0.82±0.25)mg/L(P<0.05);观察组治疗后白细胞介素-6(IL-6)(27.86±4.57)ng/L、白细胞介素-8(IL-8)(11.79±3.38)μg/L、白细胞介素-17A(IL-17A)(1.25±0.23)ng/L明显低于对照组的(39.61±6.24)ng/L、(19.07±4.11)μg/L、(1.89±0.31)ng/L,白细胞介素-10(IL-10)(42.87±6.58)ng/ml、干扰素-γ(IFN-γ)(22.84±6.95)μg/L明显高于对照组的(29.06±4.23)ng/ml、(11.68±3.72)μg/L(P<0.05);观察组治疗后高热不退、烦躁、神识昏蒙、食少纳呆、脘腹胀满积分分别为(1.02±0.20)、(0.97±0.18)、(0.95±0.21)、(0.92±0.16)、(0.90±0.17)分,明显低于对照组的(1.69±0.23)、(1.62±0.21)、(1.58±0.24)、(1.53±0.21)、(1.58±0.22)分(P<0.05)。结论清开灵软胶囊辅助治疗小儿脓毒症毒热证的临床疗效显著,能有效抑制炎症反应和凝血功能恶化,降低致炎因子水平,增加抗炎因子释放,对改善预后有积极意义。Objective To explore the clinical efficacy of Qingkailing soft capsule in adjuvant treatment of sepsis children with heat-toxin syndrome.Methods 67 cases of sepsis child patients with heat-toxin syndrome were divided into control group(n=39)and observation group(n=28)according to different treatment methods.The control group was treated with conventional treatment,and the observation group was treated with Qingkailing soft capsule on the basis of the control group.The clinical efficacy,inflammation and coagulation markers,cytokines and traditional Chinese medicine syndrome scores were compared between the two groups.Results The total effective rate of the observation group was 96.43%,which was significantly higher than 74.36%of the control group(P<0.05).After treatment,the white blood cell count(WBC),hypersensitive C-reactive protein(hs-CRP),procalcitonin(PCT),neutrophil percentage(NET%)and D-dimer were(7.04±1.03)×10^(9)/L,(14.32±3.28)mg/L,(0.11±0.03)μg/L,(44.60±5.02)%and(0.67±0.23)mg/L in the observation group,which were lower than(9.11±1.12)×10^(9)/L,(16.51±1.79)mg/L,(0.38±0.09)μg/L,(67.31±6.73)%and(0.82±0.25)mg/L in the control group(P<0.05).After treatment,the observation group had interleukin-6(IL-6)of(27.86±4.57)ng/L,interleukin-8(IL-8)of(11.79±3.38)μg/L,and interleukin-17A of(IL-17A)(1.25±0.23)ng/L,which were significantly lower than(39.61±6.24)ng/L,(19.07±4.11)μg/L,and(1.89±0.31)ng/L in the control group;the observation group had interleukin-10(IL-10)of(42.87±6.58)ng/ml and interferon-γof(22.84±6.95)μg/L,which were significantly higher than(29.06±4.23)ng/ml and(11.68±3.72)μg/L in the control group(P<0.05).After treatment,the scores of unabating high fever,irritability,mental confusion,food less and anorexia,and abdominal distention in the observation group were(1.02±0.20),(0.97±0.18),(0.95±0.21),(0.92±0.16),and(0.90±0.17)points,which were significantly lower than(1.69±0.23),(1.62±0.21),(1.58±0.24),(1.53±0.21),and(1.58±0.22)points in the control group(P<0.05).Conclusi

关 键 词：小儿脓毒症 毒热证 清开灵软胶囊 临床疗效 炎症 中医证候 

分 类 号：R28[医药卫生—中药学]