低剂量阿司匹林与硫酸镁联合治疗子痫前期的效果观察  

Efficacy of low-dose Aspirin combined with Magnesium Sulfate in the treatment of preeclampsia

作　　者：刘登彩 LIU Dengcai(Department of Medical,the People's Hospital of Xintai City,Tai'an,Shandong 271200,China)

机构地区：[1]新泰市人民医院医务部,山东泰安271200

出　　处：《医药前沿》2025年第10期50-52,56,共4页Journal of Frontiers of Medicine

摘　　要：目的探讨低剂量阿司匹林与硫酸镁联合治疗子痫前期(PE)的效果。方法选取2021年5月—2023年2月新泰市人民医院收治的120例PE患者,按随机数字表法分为对照组和观察组。对照组(60例)予以硫酸镁治疗,观察组(60例)在对照组基础上联合低剂量阿司匹林治疗,两组患者均持续治疗至妊娠终止前1周。比较两组凝血指标[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、凝血酶原活动度(PTA)]、子宫动脉血流指标[收缩期和舒张末期最大血流速度比值(S/D)、搏动指数(PI)、阻力指数(RI)]、妊娠结局、临床疗效、不良反应。结果治疗后,观察组PT和临床总有效率长于或高于对照组,APTT、FIB、PTA和S/D、PI、RI短于或低于对照组;观察组不良妊娠结局发生率低于对照组(P<0.05)。治疗期间,两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论低剂量阿司匹林与硫酸镁联合治疗PE效果显著,可改善患者凝血、子宫动脉血流指标和妊娠结局,且安全性较好。Objective To investigate the effect of low-dose Aspirin combined with Magnesium Sulfate in the treatment of preeclampsia(PE).Methods A total of 120 patients with PE admitted to the People's Hospital of Xintai City from May 2021 to February 2023 were selected and divided into control group and observation group according to random number table method.The control group received Magnesium Sulfate treatment,while the observation group received low-dose Aspirin in addition to the treatment given to the control group.Both groups continued treatment until one week before the termination of pregnancy.The coagulation indicators[activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen(FIB),prothrombin activity(PTA)],uterine artery blood flow indicators[systolic to diastolic maximum blood flew velocity ratio(S/D),pulsatility index(PI),resistance index(RI)],pregnancy outcomes,clinical efficacy,and adverse reactions were compared between the two groups.Results After treatment,the PT and clinical total effective rate of the observation group were longer or higher than those of the control group,APTT,FIB,PTA and S/D,PI,RI were shorter or lower than those of the control group;the incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group(P<0.05).During the treatment period,there was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusions Low-dose Aspirin combined with Magnesium Sulfate in the treatment of PE has a significant effect,which can improve the coagulation,uterine artery blood flow index and pregnancy outcome of patients,and has good safety.

关 键 词：子痫前期 阿司匹林 硫酸镁 凝血指标 子宫动脉血流指标 妊娠结局 

分 类 号：R714[医药卫生—妇产科学]