冠心病患者血清尿酸与高血压的相关性研究  

Correlation between serum uric acid and hypertension in patients with coronary heart disease

作　　者：王鹏[1] 贺永明[1] 贺阳[1] WANG Peng;HE Yongming;HE Yang(Emergency Department,the First Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215000,China)

机构地区：[1]苏州大学附属第一医院急诊科,江苏苏州215000

出　　处：《医药前沿》2025年第8期23-27,共5页Journal of Frontiers of Medicine

摘　　要：目的分析冠心病患者血清尿酸(SUA)与高血压的相关性,为冠心病的综合治疗提供策略。方法回顾性分析2010—2013年于苏州大学附属第一医院住院治疗的3462例冠心病患者资料,根据是否患有高血压进行分组,比较组间不同指标的差异,进一步应用Logistic回归模型分析高血压与SUA的相关性。结果高血压组2300例、对照组1162例,两组患者的SUA、血清肌酐(SCr)水平及糖尿病史、吸烟史、饮酒史情况比较,差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,在校正吸烟史、饮酒史、糖尿病史、体重指数、SCr、血清低密度脂蛋白胆固醇、年龄等混杂因素后,SUA每升高100μmol/L,总冠心病人群高血压患病风险增加21.60%[95%CI(1.118,1.322)];男性高血压患病风险增加24.00%[95%CI(1.129,1.362)];女性高血压患病风险增加10.90%[95%CI(0.910,1.350)]。将SUA作为分类变量进行五等分,与第1分位组比较,总冠心病人群中,第2、3、4分位组的高血压风险依次升高(P<0.001),第5分位组是第1分位组的1.859倍[95%CI(1.421,2.433)];性别分层分析显示,校正混杂因素后,男性第2、3、4分位组的高血压风险依次升高(P<0.001),第5分位组是第1分位组的2.001倍[95%CI(1.480,2.705)];然而女性SUA与高血压无相关性(P>0.05)。结论冠心病患者SUA与高血压具有相关性,SUA水平升高是罹患高血压的危险因素。Objective To analyze the correlation between serum uric acid(SUA)and hypertension in patients with coronary heart disease in order to provide strategies for comprehensive treatment of patients with coronary heart disease.Methods The data of 3462 patients with coronary heart disease who were hospitalized in the First Affiliated Hospital of Soochow University from 2010 to 2013 was retrospectively analyzed.The patients were grouped according to whether they had hypertension or not,and the differences of different indexes between the two groups were compared.The correlation between hypertension and SUA was further analyzed by using Logistic regression model.Results There were 2300 cases in the hypertension group and 1162 cases in the control group,and there were statistically significant differences in levels of SUA and serum creatinine(SCr),histories of diabetes,smoking and drinking between the two groups(P<0.05).Multivariate logistic regression analysis showed that after adjusting for confounding factors such as smoking history,drinking history,diabetes history,body mass index,SCr,serum low-density lipoprotein cholesterol and age,and the risk of hypertension onset in the total coronary heart disease population increased by 21.60%[95%CI(1.118,1.322)],while the risk of hypertension onset in males increased by 24.00%[95%CI(1.129,1.362)],and the risk of hypertension onset in females increased by 10.90%[95%CI(0.910,1.350)]for every 100μmol/L increased in SUA.SUA was used as a categorical variable in quintiles.Compared with that in the first quintile group,the risk of hypertension onset in the second,third and fourth quintile groups increased in turn(P<0.001),and the value in the fifth quintile group was 1.859 times that of the first quintile group[95%CI(1.421,2.433)].Gender stratification analysis showed that after adjusting for confounding factors,the risk of hypertension onset in the second,third and fourth quintile groups of males increased in turn(P<0.001),and the value in the fifth quintile group was 2.001 times t

关 键 词：冠心病 血清尿酸 高血压 相关性 危险因素 

分 类 号：R541[医药卫生—心血管疾病]