2009—2023年全球药物生殖和发育毒性研究的热点归纳与趋势  

Hot spots and trends in global drug reproductive and developmental toxicity research from 2009 to 2023

作　　者：申佰轩 王婉瑩 李映 刘传鑫 SHEN Baixuan;WANG Wanying;LI Ying;LIU Chuanxin(Henan Key Laboratory of Rare Diseases,Endocrinology and Metabolism Center,the First Affiliated Hospital,and College of Clinical Medicine of Henan University of Science and Technology,Luoyang 471003,China;Department of Pharmacy,the First Affiliated Hospital,and College of Clinical Medicine of Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]河南科技大学临床医学院,河南科技大学第一附属医院内分泌代谢中心,河南省罕见病重点实验室,洛阳市临床多组学与转化医学重点实验室,河南洛阳471003 [2]河南科技大学临床医学院,河南科技大学第一附属医院药学部,河南洛阳471003

出　　处：《药物评价研究》2025年第2期477-495,共19页Drug Evaluation Research

基　　金：国家自然科学基金资助项目(82204938);河南省医学科技公关计划联合共建项目(LHGJ20240427)。

摘　　要：目的采用文献计量学方法探讨药物的生殖与发育毒性研究热点和发展趋势。方法从Web of Science核心集中收集2009—2023年相关文献数据并利用CiteSpace,VOSviewer等工具进行可视化分析。结果共有1962篇文献纳入研究,这些文献多聚焦于药理学和毒理学领域,但对公共卫生、环境科学等领域的研究存在欠缺。近15年发文量总体呈上升趋势,至2021年达到高峰。在101个国家/地区中,美国的发文量最多且来自美国的哈佛大学被认为是最高生产力的机构,但其国际交流合作的深度与广度仍待拓展。Werler MM是同时拥有最高发文量和被引频次的作者。在766个期刊中,Reproductive Toxicology以85篇发文量位居第1位。关键词和文献分析表明沙利度胺、抗甲状腺药(ATD)、抗癫痫药(AED)等是高频研究药物,毒性机制聚焦于氧化应激、DNA损伤、细胞凋亡等。结论药物的生殖和发育毒性研究面向多学科发展,对公共卫生和环境科学等研究薄弱领域应加强关注。目前的研究重点聚焦于ATD、AED在内的多种药物毒性探索和毒理机制研究。未来应加强多学科交叉应用,积极探寻有效的抗氧化策略和减少DNA损伤及细胞凋亡的措施。Objective To explore the research hotspot and development trend of reproductive and developmental toxicity of drugs by bibliometrics.Methods Relevant publication data from 2009 to 2023 were collected from Web of Science Core Collection and visualized with tools such as CiteSpace and VOSviewer.Results A total of 1962 literatures were included in the study,most of which focused on the fields of pharmacology and toxicology,but there was a lack of research in the fields of public health and environmental science.In the past 15 years,the number of published documents has shown an overall upward trend,reaching a peak in 2021.Among the 101 countries/regions,the United States had the largest number of publications and Harvard University from the United States was considered to be the most productive institution,but the depth and breadth of its international exchanges and cooperation still need to be expanded.Werler MM was the author with both the highest number of articles and the highest number of citations.Among the 766 journals,Reproductive Toxicology(AED),etc.are highly studied drugs,and the toxic mechanism focuses on oxidative stress,DNA damage,apoptosis,etc.Conclusion The research on reproductive and developmental toxicity of drugs is developing in multiple disciplines,and more attention should be paid to the weak areas such as public health and environmental science.The current research focuses on the toxicity exploration and toxicological mechanism research of various drugs including ATD and AED.In the future,interdisciplinary application should be strengthened to actively explore effective antioxidant strategies and measures to reduce DNA damage and cell apoptosis.

关 键 词：生殖毒性 发育毒性 药物 文献计量学 CITESPACE VOSviewer 

分 类 号：R965.3[医药卫生—药理学]