红蓝光联合强脉冲光治疗丘疹脓疱型玫瑰痤疮临床疗效研究  

Study on the clinically curative effect of red-blue light combined with intense pulsed light in treating papular pustular rosacea

作　　者：赵俊平 王成良 李雪 张继刚 Zhao Junping;Wang Chengliang;Li Xue;Zhang Jigang(Department of Dermatology,PLA Rocket Force Characteristic Medical Center,Beijing 100088,China;Department of Dermatology,Qinghai Provincial Traffic Hospital,Xining 810008,China)

机构地区：[1]火箭军特色医学中心皮肤病科,北京100088 [2]青海省交通医院皮肤科,西宁810008

出　　处：《中国医学装备》2025年第3期78-82,共5页China Medical Equipment

摘　　要：目的:探讨红蓝光联合强脉冲光(IPL)治疗丘疹脓疱型玫瑰痤疮的疗效及对患者生活质量的影响。方法:回顾性选取2019年8月至2023年7月火箭军特色医学中心皮肤病科和青海省交通医院皮肤科诊治的76例丘疹脓疱型玫瑰痤疮患者,根据治疗方法的不同将其分为观察组和对照组,每组38例。对照组采用口服盐酸米诺环素治疗,观察组在对照组治疗的基础上采用87C型红蓝光治疗仪和M22型光子治疗仪给予红蓝光和IPL治疗。采用临床红斑评估量表(CEA)、研究者整体评估量表(IGA)及皮肤病生活质量指数(DLQI)评分,对比评估两组患者的临床疗效和生活质量以及不良反应发生情况。结果:观察组治疗总有效率为97.37%,明显高于对照组的84.21%,差异有统计学意义(x^(2)=3.934,P<0.05);两组治疗后IGA、CEA及DLQI评分均明显低于治疗前,且观察组治疗后IGA、CEA及DLQI评分明显低于对照组,差异均有统计学意义(t=3.820、6.725、7.937,P<0.05)。两组患者治疗后头晕、皮肤干燥、瘙痒刺痛加重以及色素沉着的不良反应发生率差异均无统计学意义(P>0.05)。结论:红蓝光联合IPL治疗丘疹脓疱型玫瑰痤疮可显著提高临床疗效,明显减轻持续性红斑等皮损症状,改善患者生活质量,且安全性好。Objective:To investigate the curative effect of red-blue light combined with intense pulsed light(IPL)in treating papular pustular rosacea,and its effect on quality of life.Methods:A total of 76 patients with papular pustular rosacea who admitted to PLA rocket force characteristic medical center and Qinghai provincial traffic hospital from August 2019 to July 2023 were retrospectively selected.According to the different treatment methods,all patients were divided into observation group and control group,with 38 patients in each group.The control group was treated with oral minocycline hydrochloride,while the observation group adopted respectively 87C type red-blue light instrument and M22 type photon therapy device to implement red-blue and IPL therapy on the basis of treatment of control group.The clinical efficacy,clinician’s erythema assessment(CEA)scale,investigator’s global assessment(IGA)scale,dermatology life quality index(DLQI)and the incidence of adverse reaction were compared between the two groups.Results:The overall effective rate of the observation group was 97.37%,which was significantly higher than 84.21%of the control group,and the difference was statistically significant(x^(2)=3.934,P<0.05).The scores of IGA,CEA and DLQI in two groups after treatment were all lower than those before treatment,and the differences of them were all significant(t=3.820,6.725,7.937,P<0.05).There were no statistically significant differences in the incidence of adverse reactions included dizziness,dry skin,worsening itching and pain and pigmentation between the two groups after treatment(P>0.05).Conclusion:Red-blue light combined with IPL can significant enhance the clinically curative effect in treating papular pustular rosacea,which can significantly reduce the symptom of skin lesions of persistent with erythema,and improve quality of life of patients.It has favorable safety.

关 键 词：玫瑰痤疮 丘疹脓疱型 红蓝光 强脉冲光(IPL) 面部红斑 生活质量 

分 类 号：R758.64[医药卫生—皮肤病学与性病学]