血液透析终末期肾病患者伴认知功能障碍的MRI研究进展  

Research advance of MRI for ESRD patients with cognitive impairment who receiving hemodialysis

作　　者：陈楚洁 肖慧 付丽媛 Chen Chujie;Xiao Hui;Fu Liyuan(Department of Radiology and Diagnosis,Fuzhou General Teaching Hospital(The 900th Hospital),Fujian University of Traditional Chinese Medicine,Fuzhou 350025,China;Department of Radiology and Diagnosis,The 900th Hospital of People's Liberation Army Joint Service Support Force,Fuzhou 350025,China)

机构地区：[1]福建中医药大学福总教学医院(第九〇〇医院)放射诊断科,福州350025 [2]中国人民解放军联勤保障部队第九〇〇医院放射诊断科,福州350025

出　　处：《中国医学装备》2025年第3期148-153,共6页China Medical Equipment

基　　金：福建省科技计划项目(2024I0038)。

摘　　要：认知功能障碍(CI)是终末期肾病(ESRD)患者中常见的并发症,早期即可在注意力、记忆力和执行力等多个领域认知下降,但ESRD患者伴CI的潜在神经病理机制很大程度上仍为未知,因此在早期阶段对其进行检测具有较大的挑战性。近年来,多模态磁共振成像(MRI)的发展使该领域的研究取得诸多进展。基于此,系统综述血液透析ESRD患者伴CI的多模态MRI研究进展,从脑结构变化、脑功能变化、脑灌注变化和脑代谢变化方面阐述MRI技术在ERSD患者CI神经病理方面的重要进展,旨在分析ESRD患者CI的潜在机制,为早期诊断和治疗提供新方向。Cognitive impairment(CI)is a common complication in patients with end-stage renal disease(ESRD),who can appear decline of the cognition at multi fields include attention,memory,and executive function at early stage.However,the potentially neuropathological mechanisms of ESRD patients with CI still is unknown to be great extent.Therefore,it is great challenge to detect patients at early stage.In recent years,the development of multi-modal magnetic resonance imaging(MRI)has taken the research of this field to gain many progress.Based on the above reasons,this review systematically explored the research advance of multi modal MRI for ESRD patients with CI who received hemodialysis,and elaborated the important progress of MRI technique in neuropathological aspect of ERSD patients with CI from the changes of brain structure,brain function,brain perfusion,and brain metabolism,which aim was to explore the potential mechanism of ESRD patients with CI,so as to provide new direction for early diagnosis and treatment.

关 键 词：终末期肾病(ESRD) 血液透析 认知功能障碍(CI) 磁共振成像(MRI) 脑功能成像 

分 类 号：R758.734[医药卫生—皮肤病学与性病学] R445.2[医药卫生—临床医学]