牛结节性皮肤病(山羊痘病毒AV41株)疫苗对奶牛的免疫效果评估  

Evaluation of the Immune Effect of Dairy Cow Nodular Dermatosis(Goat Pox Virus AV 41 Strain)Vaccine

作　　者：周继萍 王琪 张家玮 王涛[1] ZHOU Jiping;WANG Qi;ZHANG Jiawei;WANG Tao(Urumqi Animal Disease Control and Diagnosis Center,Urumqi Xinjiang 830063,China;Zhongmu Industrial Co.,Ltd,Fengtai District,Beijing 100070,China)

机构地区：[1]新疆乌鲁木齐市动物疾病控制与诊断中心,新疆乌鲁木齐830063 [2]中牧实业股份有限公司,北京100070

出　　处：《现代畜牧科技》2025年第3期53-55,共3页Modern Animal Husbandry Science & Technology

基　　金：新疆维吾尔自治区科学技术厅创新环境(人才、基地)建设专项-资源共享平台建设项目(P202307);2023年度乌鲁木齐市级技能大师工作室项目(2023-18)。

摘　　要：为掌握牛结节性皮肤病(山羊痘病毒AV41株)疫苗在实际生产中的使用效果、不良反应发生情况和免疫抗体产生情况,以期为生产实际提供科学的参考依据。该试验选取48头牛结节性皮肤病感染抗体阴性奶牛作为试验对象,以肌肉注射的方式接种该疫苗,在接种后72 h内观察并记录免疫牛的健康状况并进行28 d的跟踪观察和定期检测。结果表明,48头试验牛用ELISA试验检测在首次免疫14 d后免疫阳性合格率为70.83%,二免14 d后免疫抗体阳性率升至最高100%,直至二免60 d后抗体阳性率下降至93.75%。从该疫苗的实际市场价格、接种方式及免疫效果综合评估来看,适合用于生产实践中牛结节性皮肤病的预防。To understand the efficacy,adverse reactions,and immune antibody production of the bovine nodular skin disease(goat pox virus AV41 strain)vaccine in actual production,in order to provide scientific reference for production practice.48 cows with negative antibodies against nodular skin disease infection were selected as the experimental subjects in this experiment.The vaccine was administered by intramuscular injection,and the health status of the immunized cows was observed and recorded within 72 hours after vaccination.28 days of follow-up observation and regular testing were conducted.The results showed that,48 experimental cows were tested by ELISA,and the qualified rate of immune positivity was 70.83%after 14 days of initial immunization.The positive rate of immune antibodies increased to the highest 100%after 14 days of secondary immunization,and it was not until 60 days after secondary immunization that the positive rate of antibodies decreased to 93.75%.From the actual market price,vaccination method,and comprehensive evaluation of immune efficacy,it is suitable for the prevention of bovine nodular skin disease in production practice.

关 键 词：灭活疫苗 免疫抗体 阳性率 

分 类 号：S858.23[农业科学—临床兽医学]