过敏性肠炎对婴幼儿功能性胃肠疾病发生风险的影响研究  

A study on effects of allergic enteritis on the risk of functional gastrointestinal disorders in infants and young children

作　　者：李俊 许继志 黄腾飞 陈玲玲 黄艳 龚晓辉 LI Jun;XU Jizhi;HUANG Tengfei;CHEN Lingling;HUANG Yan;GONG Xiaohui(Department of Pediatrics,Changsha Hospital for Maternal and Child Health Care,Changsha 410007,China)

机构地区：[1]长沙市妇幼保健院儿科,长沙410007

出　　处：《中国临床新医学》2025年第3期252-256,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：湖南省儿童安全用药临床医疗技术示范基地(编号:2023SK4083)。

摘　　要：目的研究过敏性肠炎对婴幼儿功能性胃肠疾病(FGIDs)发生风险的影响。方法纳入2019年1月至2019年12月在长沙市妇幼保健院确诊为过敏性肠炎的80例患儿为过敏性肠炎组,以过敏性肠炎组患儿4岁以下无牛奶过敏史的兄弟姐妹或同期因轻微创伤在长沙市妇幼保健院急诊科治疗的就诊者共80名为对照组。过敏性肠炎组和对照组的父母每12个月接受一次电话随访,直至受试者4岁。所有过敏性肠炎患儿在内镜检查前1周内采用酶联免疫吸附法检测常见食物(牛奶、大豆、大米、小麦、鸡蛋)的IgE抗体滴度和粪便钙卫蛋白水平。记录内镜及病理检查结果。结果80例过敏性肠炎患儿中,12例(15.00%)出现FGIDs,而对照组80例中仅4例(5.00%)出现FGIDs(χ2=2.108,P=0.035)。校正年龄和性别后,多因素logistic回归分析结果显示,过敏性肠炎组发生FGIDs的比值比(OR)(95%CI)为4.39(1.03~18.68)。FGIDs与缺铁性贫血、便血持续时间及过敏性肠炎的发病年龄显著相关(P<0.05)。多因素logistic回归分析显示,较长的便血持续时间是FGIDs发生的独立危险因素[OR(95%CI)=3.14(1.72~5.74)]。结论过敏性肠炎是婴幼儿FGIDs发生的危险因素。较长的便血持续时间是FGIDs发生的独立危险因素。Objective To study the effects of allergic enteritis on the risk of functional gastrointestinal disorders(FGIDs)in infants and young children.Methods A total of 80 pediatric patients who were diagnosed with allergic enteritis in Changsha Hospital for Maternal and Child Health Care from January 2019 to December 2019 were included as allergic enteritis group,and 80 subjects who were brothers and sisters of the pediatric patients in the allergic enteritis group under 4 years old without a history of milk allergy or were treated in Changsha Hospital for Maternal and Child Health Care due to minor trauma during the same period were included as the control group.The parents of the subjects in the allergic enteritis group and the control group were followed up by telephone every 12 months until the subjects reached the age of 4 years.The immunoglobulin E(IgE)antibody titers of common foods(milk,soybean,rice,wheat and egg)and fecal calprotectin level were detected in all the pediatric patients with allergic enteritis within 1 week before endoscopy by using enzyme-linked immunosorbent assay.The results of endoscopy and pathological examination were recorded.Results Among the 80 pediatric patients with allergic enteritis,12 pediatric patients(15.00%)had FGIDs,while only 4 subjects(5.00%)in the 80 subjects of the control group had FGIDs(χ2=2.108,P=0.035).After adjusting for age and gender,multivariate logistic regression analysis showed that the odds ratio(OR)(95%CI)of FGIDs in the allergic enteritis group was 4.39(1.03-18.68).FGIDs were significantly correlated with iron deficiency anemia,duration of hematochezia and age of onset of allergic enteritis(P<0.05).Multivariate logistic regression analysis showed that longer duration of hematochezia was an independent risk factor for the occurrence of FGIDs[OR(95%CI)=3.14(1.72-5.74)].Conclusion Allergic enteritis is a risk factor for the development of FGIDs in infants and young children.Longer duration of hematochezia is an independent risk factor for the occurrence of FGIDs.

关 键 词：过敏性肠炎 婴幼儿 功能性胃肠疾病 便血持续时间 

分 类 号：R725.7[医药卫生—儿科]